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Neil L. Berinstein
Researcher at Sunnybrook Health Sciences Centre
Publications - 126
Citations - 3875
Neil L. Berinstein is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Cancer & Follicular lymphoma. The author has an hindex of 32, co-authored 124 publications receiving 3726 citations. Previous affiliations of Neil L. Berinstein include Women's College, Kolkata & Sanofi Pasteur.
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Journal ArticleDOI
Association of serum Rituximab (IDEC-C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphoma
Neil L. Berinstein,Antonio J. Grillo-Lopez,Christine A. White,I. Bence-Bruckler,David G. Maloney,Myron S. Czuczman,D. Green,J. Rosenberg,Patricia J. McLaughlin,D. Shen +9 more
TL;DR: Pharmacokinetic data suggests that certain subsets of patients may possibly benefit from increased dosing of Rituximab and studies to address this are currently underway.
Journal Article
Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines.
TL;DR: The coexpression of certain costimulatory molecules and/or cytokines, in concert with a non-self gene delivered as an intramuscular plasmid DNA immunogen, can significantly enhance Ag-specific CTL responses.
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The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer
Laszlo Radvanyi,Devender Singh-Sandhu,Scott Gallichan,Corey Lovitt,Artur Pedyczak,Gustavo V. Mallo,Kurt C. Gish,Kevin E Kwok,Wedad Hanna,Judith Zubovits,Jane E. Armes,Deon J. Venter,Jalil Hakimi,Jean M. Shortreed,Melinda Donovan,Mark Parrington,Pamela Dunn,Ray Oomen,James Tartaglia,Neil L. Berinstein +19 more
TL;DR: A comprehensive differential gene expression screen on a panel of 54 breast tumors and >200 normal tissue samples using DNA microarrays revealed 15 genes specifically overexpressed in breast cancer, a gene previously shown to be associated with three rare autosomal dominant genetic disorders known as the trichorhinophalangeal syndromes.
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Carcinoembryonic Antigen as a Target for Therapeutic Anticancer Vaccines: A Review
TL;DR: Tolerance to CEA in patients with cancer can be overcome with several different vaccination approaches, and such vaccinations are safe and immunologically active.
Journal Article
4-1BBL Cooperates with B7-1 and B7-2 in Converting a B Cell Lymphoma Cell Line into a Long-Lasting Antitumor Vaccine
TL;DR: The data show that neither B 7-1 or B7-2 alone can confer full immunogenicity to the A20 lymphoma but that the addition of 4-1BBL results in a tumor that is highly immunogenic and can confer long-lasting protection against challenge with parental tumor in vivo.