L
Lily Lu
Researcher at National Institutes of Health
Publications - 11
Citations - 3798
Lily Lu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Myeloid-derived Suppressor Cell & Adoptive cell transfer. The author has an hindex of 9, co-authored 10 publications receiving 3256 citations. Previous affiliations of Lily Lu include University of South Florida.
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Journal ArticleDOI
Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor
James N. Kochenderfer,Mark E. Dudley,Sadik H. Kassim,Robert Somerville,Robert O. Carpenter,Maryalice Stetler-Stevenson,James Chih-Hsin Yang,Giao Q. Phan,Michael S. Hughes,Richard M. Sherry,Mark Raffeld,Steven R. Feldman,Lily Lu,Yong F. Li,Lien T. Ngo,Andre Goy,Tatyana Feldman,David Spaner,Michael L. Wang,Clara C. Chen,Sarah M. Kranick,Avindra Nath,Debbie-Ann N. Nathan,Kathleen E. Morton,Mary Ann Toomey,Steven A. Rosenberg +25 more
TL;DR: The results demonstrate the feasibility and effectiveness of treating chemotherapy-refractory B-cell malignancies with anti-CD19 CAR T cells and provide strong support for further development of this approach.
Journal ArticleDOI
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
Cesar A. Corzo,Thomas Condamine,Lily Lu,Matthew J. Cotter,Je In Youn,Pingyan Cheng,Hyun Il Cho,Esteban Celis,David G. Quiceno,Tapan A. Padhya,Thomas V. McCaffrey,Judith C. McCaffrey,Dmitry I. Gabrilovich +12 more
TL;DR: The hypoxic environment of tumors dictates the phenotype of local myeloid-derived suppressor cells (MDSCs) via HIF-1a expression; hypoxia converts splenic MDSCs from specific into nonspecific suppressors.
Journal ArticleDOI
The cannabinoid system and immune modulation
Thomas W. Klein,Cathy Newton,Kellie Larsen,Lily Lu,Izabella Perkins,Liang Nong,Herman Friedman +6 more
TL;DR: It appears the immunocannabinoid system is involved in regulating the brain‐immune axis and might be exploited in future therapies for chronic diseases and immune deficiency.
Journal ArticleDOI
Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma
Stephanie L. Goff,Mark E. Dudley,Deborah Citrin,Robert Somerville,John R. Wunderlich,David N. Danforth,Daniel Zlott,James Chih-Hsin Yang,Richard M. Sherry,Udai S. Kammula,Christopher A. Klebanoff,Michael S. Hughes,Nicholas P. Restifo,Michelle M. Langhan,Thomas E. Shelton,Lily Lu,Mei Li M. Kwong,Sadia Ilyas,Nicholas D. Klemen,Eden C. Payabyab,Kathleen E. Morton,Mary Ann Toomey,Seth M. Steinberg,Donald E. White,Steven A. Rosenberg +24 more
TL;DR: Adoptive cell transfer can mediate durable complete regressions in 24% of patients with metastatic melanoma, with median survival > 3 years.
Journal ArticleDOI
Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer
Srinivas Nagaraj,Je In Youn,Hannah Weber,Cristina Iclozan,Lily Lu,Matthew J. Cotter,Colin J. Meyer,Carlos Becerra,Mayer Fishman,Scott J. Antonia,Michael B. Sporn,Karen T. Liby,Bhupendra Rawal,Ji-Hyun Lee,Dmitry I. Gabrilovich +14 more
TL;DR: CDDO-Me abrogated the immune suppressive effect of MDSCs and improved immune responses in tumor-bearing mice and cancer patients and may represent an attractive therapeutic option by enhancing the effect of cancer immunotherapy.