Michelle Lai

TL;DR: Adult-to-adult liver transplantation from a living donor is increasingly performed in the United States but is concentrated in a few large-volume centers.

TL;DR: Subgroup analysis showed the majority with fibrosis belonged to the high normal ALT group and that only a minority who were young and immune tolerant had significant findings on biopsy, and increasing age, higher ALT, higher grade of inflammation on bi autopsy, and HBeAg positivity predicted fibrosis.

TL;DR: 12-week administration of GS-0976 20 mg decreased hepatic steatosis, selected markers of fibrosis, and liver biochemistry, and the relation between dose and efficacy was evaluated.

TL;DR: These studies identify BDK and PPM1K as a ChREBP-regulated node that integrates BCAA and lipid metabolism and manipulation of the BDK:P PM1K ratio relieves key metabolic disease phenotypes in a genetic model of severe obesity.

TL;DR: In a phase 2b study of 162 patients with NASH, cirrhosis, and portal hypertension, 1 year of biweekly infusion of belapectin was safe but not associated with significant reduction in HVPG or fibrosis, compared with placebo, however, in a subgroup analysis of patients without esophageal varices, 2 mg/kg bela Expectin did reduce HvPG and development of varices.