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Debora W. Lin
Researcher at Stanford University
Publications - 8
Citations - 1586
Debora W. Lin is an academic researcher from Stanford University. The author has contributed to research in topics: Drug delivery & Membrane. The author has an hindex of 8, co-authored 8 publications receiving 1509 citations. Previous affiliations of Debora W. Lin include Massachusetts Institute of Technology & Johns Hopkins University.
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Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells.
Shyni Varghese,Nathaniel S. Hwang,Adam C. Canver,Parnduangji Theprungsirikul,Debora W. Lin,Jennifer H. Elisseeff +5 more
TL;DR: The morphogenetic role of bioactive scaffold-mediated microenvironment on temporal pattern of cartilage specific gene expressions and subsequent matrix production during MSC chondrogenesis is demonstrated.
Posted Content
A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery
Todd Hoare,Jesus Santamaria,Gerardo F. Goya,Silvia Irusta,Debora W. Lin,Samantha Lau,Robert F. Padera,Robert Langer,Daniel S. Kohane +8 more
TL;DR: Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field.
Journal ArticleDOI
A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery
Todd Hoare,Jesus Santamaria,Gerardo F. Goya,Silvia Irusta,Debora W. Lin,Samantha Lau,Robert F. Padera,Robert Langer,Daniel S. Kohane +8 more
TL;DR: In this article, an on-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices and the total drug dose delivered was directly proportional to the duration of the “on” pulse.
Journal ArticleDOI
Magnetically-triggered Nanocomposite Membranes: a Versatile Platform for Triggered Drug Release
Todd Hoare,Brian P. Timko,Jesus Santamaria,Gerardo F. Goya,Silvia Irusta,Debora W. Lin,Samantha Lau,Robert Langer,Daniel S. Kohane +8 more
TL;DR: In this paper, drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field.
Journal ArticleDOI
Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release
Todd Hoare,Brian P. Timko,Brian P. Timko,Jesus Santamaria,Gerardo F. Goya,Silvia Irusta,Samantha Lau,Cristina F. Stefanescu,Debora W. Lin,Robert Langer,Daniel S. Kohane +10 more
TL;DR: In this article, the phase transition temperature of the nanogel, the loading density of nanogels in the membrane, and the membrane thickness of a nanocomposite membrane was used for on-state delivery of drugs over at least 2 orders of magnitude.