S
Shyni Varghese
Researcher at Duke University
Publications - 142
Citations - 8972
Shyni Varghese is an academic researcher from Duke University. The author has contributed to research in topics: Self-healing hydrogels & Embryonic stem cell. The author has an hindex of 47, co-authored 128 publications receiving 7616 citations. Previous affiliations of Shyni Varghese include National Chemical Laboratory & Johns Hopkins University.
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Journal ArticleDOI
Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration.
Dong-An Wang,Dong-An Wang,Shyni Varghese,Blanka Sharma,Iossif Strehin,Sara Fermanian,Justin M. Gorham,D. Howard Fairbrother,Brett M. Cascio,Jennifer H. Elisseeff +9 more
TL;DR: The biopolymer chondroitin sulphate, one of the major components of cartilage extracellular matrix, is used to develop a novel bioadhesive that is readily applied and acts quickly and led to mechanical stability of the hydrogel and tissue repair in cartilage defects.
Journal ArticleDOI
Rapid self-healing hydrogels.
Ameya Phadke,Chao Zhang,Bedri Arman,Cheng-Chih Hsu,R. A. Mashelkar,Ashish K. Lele,Michael J. Tauber,Gaurav Arya,Shyni Varghese +8 more
TL;DR: It is demonstrated that permanently cross-linked hydrogels can be engineered to exhibit self-healing in an aqueous environment, and how secondary interactions could be harnessed to introduce new functions to chemically cross- linked polymeric systems is revealed.
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Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells.
Shyni Varghese,Nathaniel S. Hwang,Adam C. Canver,Parnduangji Theprungsirikul,Debora W. Lin,Jennifer H. Elisseeff +5 more
TL;DR: The morphogenetic role of bioactive scaffold-mediated microenvironment on temporal pattern of cartilage specific gene expressions and subsequent matrix production during MSC chondrogenesis is demonstrated.
Journal ArticleDOI
Controlled differentiation of stem cells.
TL;DR: This review focuses on recent emerging findings and well-characterized differentiation models of human embryonic stem cells and also discusses about various strategies that have been used in stem cell expansion.
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Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling
Yu Ru V. Shih,Yu Ru V. Shih,Yongsung Hwang,Ameya Phadke,Heemin Kang,Nathaniel S. Hwang,Eduardo J. Caro,Steven Nguyen,Michael Siu,Emmanuel A. Theodorakis,Nathan C. Gianneschi,Kenneth S. Vecchio,Shu Chien,Oscar K. Lee,Shyni Varghese +14 more
TL;DR: A previously unknown mechanism, phosphate-ATP-adenosine metabolic signaling, by which the CaP-rich mineral environment in bone tissues promotes osteogenic differentiation of human mesenchymal stem cells is unraveled.