D
Deborah J. Lenschow
Researcher at University of Chicago
Publications - 12
Citations - 6677
Deborah J. Lenschow is an academic researcher from University of Chicago. The author has contributed to research in topics: CD28 & T cell. The author has an hindex of 11, co-authored 12 publications receiving 6463 citations. Previous affiliations of Deborah J. Lenschow include University of Illinois at Chicago & Northwestern University.
Papers
More filters
Journal ArticleDOI
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
Benoît L. Salomon,Deborah J. Lenschow,Lesley Rhee,Neda Ashourian,Bhagarith Singh,Arlene H. Sharpe,Jeffrey A. Bluestone +6 more
TL;DR: The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases.
Journal ArticleDOI
CTLA-4 can function as a negative regulator of T cell activation
Theresa L. Walunas,Deborah J. Lenschow,Christina Y. Bakker,Peter S. Linsley,Gordon J. Freeman,Jonathan Green,Craig B. Thompson,Craig B. Thompson,Jeffrey A. Bluestone +8 more
TL;DR: Results suggest that the MAb may obstruct the interaction of CTLA-4 with its natural ligand and block a negative signal, or directly signal T cells to down-regulate immune function.
Journal ArticleDOI
Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg
Deborah J. Lenschow,Y. Zeng,Thistlethwaite,A Montag,William E. Brady,MG Gibson,Peter S. Linsley,Jeffrey A. Bluestone +7 more
TL;DR: CTLA4lg therapy blocked human pancreatic islet rejection in mice by directly affecting T cell recognition of B7+ antigen-presenting cells and induced long-term, donor-specific tolerance, which may have applications to human organ transplantation.
Journal ArticleDOI
CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune Diabetes
Deborah J. Lenschow,Kevan C. Herold,Lesley Rhee,Bina Patel,Ann Koons,Hui Yu Qin,Elaine Fuchs,Bhagarith Singh,Craig B. Thompson,Craig B. Thompson,Jeffrey A. Bluestone +10 more
TL;DR: The early differentiation of naive diabetogenic T cells into the Th2 subset is dependent upon CD28 signaling and extends the understanding of the importance of Th1/Th2 balance in the regulation of this spontaneous autoimmune disease.
Journal ArticleDOI
Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
Stephen D. Miller,Carol L. Vanderlugt,Deborah J. Lenschow,Jonathan G. Pope,Nitin J. Karandikar,Mauro C. Dal Canto,Jeffrey A. Bluestone +6 more
TL;DR: It is suggested that the maintenance of autoimmune reactivity in EAE depends on CD28/B7-1-dependent costimulation of newly recruited T cells responsible for epitope spreading.