M
Mauro C. Dal Canto
Researcher at Northwestern University
Publications - 92
Citations - 11840
Mauro C. Dal Canto is an academic researcher from Northwestern University. The author has contributed to research in topics: Virus & Demyelinating disease. The author has an hindex of 38, co-authored 92 publications receiving 11456 citations. Previous affiliations of Mauro C. Dal Canto include University of Chicago & University of Bari.
Papers
More filters
Journal ArticleDOI
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.
Mark E. Gurney,Haifeng Pu,Arlene Y. Chiu,Mauro C. Dal Canto,Cynthia Y. Polchow,Denise D. Alexander,Jan Caliendo,Afif Hentati,Young W. Kwon,Han Xiang Deng,W. Chen,Ping Zhai,Robert L. Sufit,Teepu Siddique +13 more
TL;DR: In this article, the authors found that mutations of human Cu,Zn superoxide dismutase (SOD) contribute to the pathogenesis of familial amyotrophic lateral sclerosis (ALS).
Journal ArticleDOI
Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.
Scott Koenig,Howard E. Gendelman,Jan M. Orenstein,Mauro C. Dal Canto,Gholam H. Pezeshkpour,Margaret Yungbluth,Frank Janotta,Allen J. Aksamit,Malcolm A. Martin,Anthony S. Fauci +9 more
TL;DR: The identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals and these cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients.
Journal ArticleDOI
Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS)
TL;DR: It is shown that although simple overexpression of SOD may be injurious to motor neurons, albeit very mildly, the mutant form is necessary to produce both clinical disease and severe pathological changes which, in the chronic stage of the disease, have striking similarities to human familial ALS.
Journal ArticleDOI
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
Han Xiang Deng,Yong Shi,Yoshiaki Furukawa,Hong Zhai,Ronggen Fu,Erdong Liu,George Gorrie,Mohammad S. Khan,Wu Yen Hung,Eileen H. Bigio,Thomas J. Lukas,Mauro C. Dal Canto,Thomas V. O'Halloran,Teepu Siddique +13 more
TL;DR: Findings provide evidence of direct links among oxidation, protein aggregation, mitochondrial damage, and SOD1-mediated ALS, with possible applications to the aging process and other late-onset neurodegenerative disorders, and rational therapy can now be developed and tested.
Journal ArticleDOI
HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology.
Herbert Budka,Clayton A. Wiley,Paul Kleihues,Juan Artigas,Arthur K. Asbury,Eun Sook Cho,David R. Cornblath,Mauro C. Dal Canto,Umberto DeGirolami,Dennis W. Dickson,Leon G. Epstein,Margaret M. Esiri,Felice Giangaspero,Georg Gosztonyi,Françoise Gray,John W. Griffin,Dominique Hénin,Yuzo Iwasaki,Robert S. Janssen,Richard T. Johnson,Peter L. Lantos,William D. Lyman,Justin C. McArthur,Kazuo Nagashima,Nancy S. Peress,Carol K. Petito,Richard W. Price,Roy H. Rhodes,Marc K. Rosenblum,Gérard Said,Francesco Scaravilli,Leroy R. Sharer,Harry V. Vinters +32 more
TL;DR: Herbert Budka 1, Clayton A. Wiley 2, Paul Kleihues 3, Juan Artigas 4, Arthur K. Asbury 5, Eun-Sook Cho 6, David R. Cornblath 7, Mauro C. Dal Canto 8, Umberto DeGirolami 9, Dennis Dickson 10, Leon G. Epstein 11, Margaret M. Esiri 12, Felice Giangaspero 13, Georg Gosztonyi 14,