T
Theresa L. Walunas
Researcher at Northwestern University
Publications - 75
Citations - 11680
Theresa L. Walunas is an academic researcher from Northwestern University. The author has contributed to research in topics: Medicine & T cell. The author has an hindex of 28, co-authored 56 publications receiving 10906 citations. Previous affiliations of Theresa L. Walunas include Rosalind Franklin University of Medicine and Science & University of Illinois at Chicago.
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Journal ArticleDOI
Cd28/b7 system of t cell costimulation
TL;DR: This review summarizes the state of CD28/B7 immunobiology both in vitro and in vivo; summarizes the many experiments that have led to the current understanding of the participants in this complex receptor/ligand system; and illustrates the current models for CD28-mediated T cell and B cell regulation.
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CTLA-4 can function as a negative regulator of T cell activation
Theresa L. Walunas,Deborah J. Lenschow,Christina Y. Bakker,Peter S. Linsley,Gordon J. Freeman,Jonathan Green,Craig B. Thompson,Craig B. Thompson,Jeffrey A. Bluestone +8 more
TL;DR: Results suggest that the MAb may obstruct the interaction of CTLA-4 with its natural ligand and block a negative signal, or directly signal T cells to down-regulate immune function.
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Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis
Natalia Ivanova,Alexei Sorokin,Iain Anderson,Nathalie Galleron,Benjamin Candelon,Vinayak Kapatral,Anamitra Bhattacharyya,Gary Reznik,Natalia Mikhailova,Alla Lapidus,Lien Chu,Michael Mazur,Eugene Goltsman,Niels Bent Larsen,Mark D'Souza,Theresa L. Walunas,Yuri Grechkin,Gordon D. Pusch,Robert Haselkorn,Michael Fonstein,S. Dusko Ehrlich,Ross Overbeek,Nikos C. Kyrpides +22 more
TL;DR: The sequencing and analysis of the type strain B. cereus ATCC 14579 together with the gapped genome of B. anthracis A2012 enables the comparative analysis to clarify the phylogeny of the cereus group, and the latter to determine plasmid-independent species-specific markers.
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CTLA-4 ligation blocks CD28-dependent T cell activation.
TL;DR: The results demonstrate that the primary effect of CTLA-4 ligation is not the induction of apoptosis, but does inhibit CD28- dependent IL-2 production and cell cycle progression of activated T cells.
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The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution
M. van de Guchte,S. Penaud,Christine Grimaldi,Valérie Barbe,Kevin Bryson,Kevin Bryson,Pierre Nicolas,Corinne Robert,Sophie Oztas,Sophie Mangenot,Arnaud Couloux,Valentin Loux,Rozenn Dervyn,Robert Bossy,Bolotin Ap,Jean-Michel Batto,Theresa L. Walunas,J.-F. Gibrat,Philippe Bessières,Jean Weissenbach,Stanislav Dusko Ehrlich,Emmanuelle Maguin +21 more
TL;DR: The results indicate the adaptation of L. bulgaricus from a plant-associated habitat to the stable protein and lactose-rich milk environment through the loss of superfluous functions and protocooperation with Streptococcus thermophilus.