J
Jeremy F. Reiter
Researcher at University of California, San Francisco
Publications - 115
Citations - 12967
Jeremy F. Reiter is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cilium & Ciliogenesis. The author has an hindex of 50, co-authored 104 publications receiving 10996 citations. Previous affiliations of Jeremy F. Reiter include University of California, Berkeley.
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Journal ArticleDOI
Vertebrate Smoothened functions at the primary cilium
Kevin C. Corbit,Pia Aanstad,Veena Singla,Andrew R. Norman,Didier Y.R. Stainier,Jeremy F. Reiter +5 more
TL;DR: It is shown that mammalian Smoothened (Smo), a seven-transmembrane protein essential for Hh signalling, is expressed on the primary cilium, and Hh-dependent translocation to cilia is essential for Smo activity, suggesting that Smo acts at thePrimary cilia.
Journal ArticleDOI
The primary cilium as the cell's antenna : signaling at a sensory organelle
Veena Singla,Jeremy F. Reiter +1 more
TL;DR: This new appreciation of primary cilia as cellular antennae that sense a wide variety of signals could help explain why ciliary defects underlie such a wide range of human disorders, including retinal degeneration, polycystic kidney disease, Bardet-Biedl syndrome, and neural tube defects.
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Genes and molecular pathways underpinning ciliopathies
TL;DR: Investigating ciliopathies has helped to understand the molecular mechanisms by which the cilium-associated basal body functions in early ciliogenesis, as well as how the transition zone functions in ciliary gating, and how intraflagellar transport enables cargo trafficking and signalling.
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A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition
Francesc R. Garcia-Gonzalo,Kevin C. Corbit,María Salomé Sirerol-Piquer,Gokul Ramaswami,Edgar A. Otto,Thomas R. Noriega,Allen D. Seol,Jon F. Robinson,Christopher L. Bennett,Dragana Josifova,José Manuel García-Verdugo,Nicholas Katsanis,Friedhelm Hildebrandt,Friedhelm Hildebrandt,Jeremy F. Reiter +14 more
TL;DR: A transition zone complex of Meckel and Joubert syndrome proteins regulates ciliary assembly and trafficking, suggesting that transition zone dysfunction is the cause of these ciliopathies.
Journal ArticleDOI
Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways
Liyun Sang,Julie J. Miller,Kevin C. Corbit,Rachel H. Giles,Matthew J. Brauer,Edgar A. Otto,Lisa M. Baye,Xiaohui Wen,Suzie J. Scales,Mandy Kwong,Erik Huntzicker,Mindan K. Sfakianos,Wendy Sandoval,J. Fernando Bazan,Priya Kulkarni,Francesc R. Garcia-Gonzalo,Allen D. Seol,John F. O'Toole,Susanne Held,Heiko Reutter,William S. Lane,Muhammad Rafiq,Abdul Noor,Muhammad Ansar,Akella Radha Rama Devi,Val C. Sheffield,Val C. Sheffield,Diane C. Slusarski,John B. Vincent,Dan Doherty,Friedhelm Hildebrandt,Friedhelm Hildebrandt,Jeremy F. Reiter,Peter K. Jackson +33 more
TL;DR: This study further illustrates the power of linking proteomic networks and human genetics to uncover critical disease pathways and identified ATXN10 and TCTN2 as new NPHP-JBTS genes, and the Tctn2 mouse knockout shows neural tube and Hedgehog signaling defects.