J
John Chant
Researcher at Harvard University
Publications - 49
Citations - 8826
John Chant is an academic researcher from Harvard University. The author has contributed to research in topics: Budding & Cell polarity. The author has an hindex of 34, co-authored 49 publications receiving 8690 citations. Previous affiliations of John Chant include University of California, San Francisco & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
A Protein Interaction Map of Drosophila melanogaster
Loic Giot,Joel S. Bader,Cory Brouwer,Amitabha Chaudhuri,B. Kuang,Ying Li,Y. L. Hao,C. E. Ooi,Brian C. Godwin,E. Vitols,G. Vijayadamodar,Pascale Pochart,H. Machineni,M. Welsh,Yong Kong,B. Zerhusen,Rachel D. Malcolm,Z. Varrone,A. Collis,M. Minto,S. Burgess,L. McDaniel,E. Stimpson,F. Spriggs,Julia Williams,K. Neurath,N. Ioime,M. Agee,E. Voss,K. Furtak,R. Renzulli,N. Aanensen,S. Carrolla,E. Bickelhaupt,Y. Lazovatsky,A. DaSilva,Jinhui Zhong,Clement A. Stanyon,Russell L. Finley,Kevin P. White,Michael S. Braverman,Thomas P. Jarvie,Steven Allen Gold,M. Leach,James R. Knight,Richard A. Shimkets,Michael P. McKenna,John Chant,Jonathan M. Rothberg +48 more
TL;DR: This map serves as a starting point for a systems biology modeling of multicellular organisms, including humans, and recapitulated known pathways, extended pathways, and uncovered previously unknown pathway components.
Journal ArticleDOI
Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade
Nathalie Lamarche,Nicolas Tapon,Lisa Stowers,Peter D. Burbelo,Pontus Aspenström,Tina Bridges,John Chant,Alan Hall +7 more
TL;DR: It is concluded that Rac and Cdc42 control MAP kinase pathways and actin cytoskeleton organization independently through distinct downstream targets.
Journal ArticleDOI
Gaining confidence in high-throughput protein interaction networks
TL;DR: A logistic regression approach is presented that uses statistical and topological descriptors to predict the biological relevance of protein-protein interactions obtained from high-throughput screens for yeast, and other sources of information are used to validate the model predictions without bias or cross-pollution.
Journal ArticleDOI
Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway.
John Chant,Ira Herskowitz +1 more
TL;DR: Four genes, BUD1-BUD4, necessary for the axial pattern are identified by isolating mutants of alpha cells that do not exhibit this pattern, indicating the existence of a basal budding pattern, requiring no BUD products, that is random.
Journal ArticleDOI
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42
TL;DR: It is shown that, in T cells, the mammalian Ras-related GTPase CDC42 can regulate the polarization of both actin and microtubules toward antigen-presenting cells but is not involved in other T-cell signaling processes such as those which culminate in interleukin 2 production.