D
Dedreia Tull
Researcher at University of Melbourne
Publications - 90
Citations - 4352
Dedreia Tull is an academic researcher from University of Melbourne. The author has contributed to research in topics: Metabolomics & Flagellum. The author has an hindex of 31, co-authored 88 publications receiving 3663 citations. Previous affiliations of Dedreia Tull include University of British Columbia & University of Guelph.
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Journal ArticleDOI
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
Alison N. Thorburn,Craig R. M. McKenzie,Sj Shen,Dragana Stanley,Laurence Macia,Linda J. Mason,Laura K Roberts,Connie H.Y. Wong,Raymond Shim,Remy Robert,Nina Chevalier,Jian Tan,Eliana Mariño,Robert J. Moore,Lee H. Wong,Malcolm J. McConville,Dedreia Tull,Lisa Wood,Vanessa E. Murphy,Joerg Mattes,Peter G. Gibson,Charles R. Mackay +21 more
TL;DR: It is shown that feeding mice a high-fibre diet yields a distinctive gut microbiota, which increases the levels of the short-chain fatty acid, acetate, which led to marked suppression of allergic airways disease (AAD), by enhancing T-regulatory cell numbers and function.
Journal ArticleDOI
VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium
Tara Karnezis,Ramin Shayan,Carol Caesar,Carol Caesar,Carol Caesar,Sally Roufail,Sally Roufail,Sally Roufail,Nicole C. Harris,Kathryn Ardipradja,Kathryn Ardipradja,Kathryn Ardipradja,You F Zhang,You F Zhang,You F Zhang,Steven P. Williams,Rae H Farnsworth,Rae H Farnsworth,Rae H Farnsworth,Ming Gene Chai,Thusitha Rupasinghe,Dedreia Tull,Megan E. Baldwin,Erica K. Sloan,Stephen B. Fox,Stephen B. Fox,Marc G. Achen,Marc G. Achen,Marc G. Achen,Steven A. Stacker,Steven A. Stacker,Steven A. Stacker +31 more
TL;DR: Collecting lymphatics play an active and important role in metastasis and may provide a therapeutic target to restrict tumor spread and suggest a control point for cancer metastasis within the collecting lymphatic endothelium, which links VEGF-D/VEgFR-2/VEGFR-3 and the prostaglandin pathways.
Journal ArticleDOI
Normalizing and integrating metabolomics data.
Alysha M De Livera,Daniel A. Dias,David P De Souza,Thusitha Rupasinghe,James Pyke,Dedreia Tull,Ute Roessner,Malcolm J. McConville,Terence P. Speed +8 more
TL;DR: This work presents a broadly applicable method for the removal of unwanted variation arising from various sources for the identification of differentially abundant metabolites and, hence, for the systematic integration of data on the same quantities from different sources.
Journal ArticleDOI
Crystallographic observation of a covalent catalytic intermediate in a beta-glycosidase.
TL;DR: The active-site architecture of this covalent intermediate of a retaining β-1,4-glycanase gives insights into both the classical double-displacement catalytic mechanism and the basis for the enzyme's specificity.
Journal ArticleDOI
Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment
Sarah A. Best,Sarah A. Best,David P De Souza,Ariena Kersbergen,Antonia N. Policheni,Antonia N. Policheni,Saravanan Dayalan,Dedreia Tull,Vivek Rathi,Daniel H.D. Gray,Daniel H.D. Gray,Matthew E. Ritchie,Matthew E. Ritchie,Malcolm J. McConville,Kate D. Sutherland,Kate D. Sutherland +15 more
TL;DR: It is demonstrated that inactivation of Keap1 and Pten in the mouse lung promotes adenocarcinoma formation and the ability to exploit both metabolic and immune characteristics in the detection and treatment of lung tumors harboring KEAP1/NRF2 pathway alterations is highlighted.