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Thusitha Rupasinghe
Researcher at University of Melbourne
Publications - 71
Citations - 2541
Thusitha Rupasinghe is an academic researcher from University of Melbourne. The author has contributed to research in topics: Lipid metabolism & Lipidomics. The author has an hindex of 24, co-authored 65 publications receiving 1940 citations. Previous affiliations of Thusitha Rupasinghe include University of Auckland & La Trobe University.
Papers
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Journal ArticleDOI
VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium
Tara Karnezis,Ramin Shayan,Carol Caesar,Carol Caesar,Carol Caesar,Sally Roufail,Sally Roufail,Sally Roufail,Nicole C. Harris,Kathryn Ardipradja,Kathryn Ardipradja,Kathryn Ardipradja,You F Zhang,You F Zhang,You F Zhang,Steven P. Williams,Rae H Farnsworth,Rae H Farnsworth,Rae H Farnsworth,Ming Gene Chai,Thusitha Rupasinghe,Dedreia Tull,Megan E. Baldwin,Erica K. Sloan,Stephen B. Fox,Stephen B. Fox,Marc G. Achen,Marc G. Achen,Marc G. Achen,Steven A. Stacker,Steven A. Stacker,Steven A. Stacker +31 more
TL;DR: Collecting lymphatics play an active and important role in metastasis and may provide a therapeutic target to restrict tumor spread and suggest a control point for cancer metastasis within the collecting lymphatic endothelium, which links VEGF-D/VEgFR-2/VEGFR-3 and the prostaglandin pathways.
Journal ArticleDOI
Insights Into Oxidized Lipid Modification in Barley Roots as an Adaptation Mechanism to Salinity Stress
Dingyi Yu,Dingyi Yu,Berin A. Boughton,Camilla Beate Hill,Ivo Feussner,Ute Roessner,Thusitha Rupasinghe +6 more
TL;DR: The hypothesis that salt-induced oxidative damage to membrane lipids can be used as an indication of salt stress tolerance in barley roots under salinity stress is supported.
Journal ArticleDOI
Normalizing and integrating metabolomics data.
Alysha M De Livera,Daniel A. Dias,David P De Souza,Thusitha Rupasinghe,James Pyke,Dedreia Tull,Ute Roessner,Malcolm J. McConville,Terence P. Speed +8 more
TL;DR: This work presents a broadly applicable method for the removal of unwanted variation arising from various sources for the identification of differentially abundant metabolites and, hence, for the systematic integration of data on the same quantities from different sources.
Journal ArticleDOI
Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment
James F. Markworth,Luke Vella,Benjamin S. Lingard,Dedreia Tull,Thusitha Rupasinghe,Andrew J. Sinclair,Krishna Rao Maddipati,David Cameron-Smith +7 more
TL;DR: The findings show that acute proinflammatory signals are mechanistically linked to the induction of a biological active inflammatory resolution program, regulated by proresolving lipid mediators during postexercise recovery, and are regulated by ibuprofen treatment.
Journal ArticleDOI
Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post‐transcriptional regulator Ccr4‐Pop2
Michael J Dagley,Ian E Gentle,Traude H. Beilharz,Filomena Pettolino,Julianne T. Djordjevic,Tricia L. Lo,Nathalie Uwamahoro,Thusitha Rupasinghe,Dedreja L. Tull,Malcolm J. McConville,Cécile Beaurepaire,André Nantel,André Nantel,Trevor Lithgow,Aaron P. Mitchell,Ana Traven +15 more
TL;DR: This study provides the basis for an integrative view of mitochondrial function in fungal cell wall biogenesis and resistance to echinocandin antifungal drugs.