M
Megan E. Baldwin
Researcher at Ludwig Institute for Cancer Research
Publications - 26
Citations - 4159
Megan E. Baldwin is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Lymphangiogenesis & Vascular endothelial growth factor C. The author has an hindex of 17, co-authored 25 publications receiving 4022 citations. Previous affiliations of Megan E. Baldwin include Royal Melbourne Hospital.
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Journal ArticleDOI
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics.
Steven A. Stacker,Carol Caesar,Megan E. Baldwin,Gillian E. Thornton,Richard A. Williams,Remko Prevo,David A. Jackson,Shin-Ichi Nishikawa,Hajime Kubo,Hajime Kubo,Marc G. Achen +10 more
TL;DR: It is demonstrated that lymphatics can be established in solid tumors and implicates VEGF family members in determining the route of metastatic spread and could be blocked with an antibody specific for V EGF-D.
Journal ArticleDOI
Lymphangiogenesis and cancer metastasis.
Steven A. Stacker,Marc G. Achen,Marc G. Achen,Lotta Jussila,Lotta Jussila,Megan E. Baldwin,Megan E. Baldwin,Kari Alitalo,Kari Alitalo +8 more
TL;DR: In this paper, the authors reviewed recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours are associated with an enhanced metastatic process.
Journal ArticleDOI
The role of tumor lymphangiogenesis in metastatic spread
TL;DR: These studies demonstrate that tumor lymphangiogenesis is a major component of the metastatic process and implicate members of the VEGF family of growth factors as key mediators of lymphang iogenesis in both normal biology and tumors.
Journal ArticleDOI
Vascular endothelial growth factor D is dispensable for development of the lymphatic system.
Megan E. Baldwin,Michael M. Halford,Sally Roufail,Richard A. Williams,Margaret L. Hibbs,Dianne Grail,Hajime Kubo,Steven A. Stacker,Marc G. Achen +8 more
TL;DR: The lack of a profound lymphatic phenotype in Veg f-d-deficient mice suggests that Vegf-d does not play a major role in lymphatic development or that VegF-c or another, as-yet-unknown activating Vegfr-3 ligand can compensate for Vegd-d during development.
Journal ArticleDOI
VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium
Tara Karnezis,Ramin Shayan,Carol Caesar,Carol Caesar,Carol Caesar,Sally Roufail,Sally Roufail,Sally Roufail,Nicole C. Harris,Kathryn Ardipradja,Kathryn Ardipradja,Kathryn Ardipradja,You F Zhang,You F Zhang,You F Zhang,Steven P. Williams,Rae H Farnsworth,Rae H Farnsworth,Rae H Farnsworth,Ming Gene Chai,Thusitha Rupasinghe,Dedreia Tull,Megan E. Baldwin,Erica K. Sloan,Stephen B. Fox,Stephen B. Fox,Marc G. Achen,Marc G. Achen,Marc G. Achen,Steven A. Stacker,Steven A. Stacker,Steven A. Stacker +31 more
TL;DR: Collecting lymphatics play an active and important role in metastasis and may provide a therapeutic target to restrict tumor spread and suggest a control point for cancer metastasis within the collecting lymphatic endothelium, which links VEGF-D/VEgFR-2/VEGFR-3 and the prostaglandin pathways.