J
Jian Tan
Researcher at University of Sydney
Publications - 25
Citations - 5028
Jian Tan is an academic researcher from University of Sydney. The author has contributed to research in topics: Gut flora & Immune system. The author has an hindex of 13, co-authored 25 publications receiving 3259 citations. Previous affiliations of Jian Tan include Discovery Institute & Monash University.
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Book ChapterDOI
The role of short-chain fatty acids in health and disease.
Jian Tan,Craig R. M. McKenzie,Maria Potamitis,Alison N. Thorburn,Charles R. Mackay,Laurence Macia +5 more
TL;DR: The role of SCFAs as a major player in maintenance of gut and immune homeostasis is highlighted, and their levels are regulated by diet are provided a new basis to explain the increased prevalence of inflammatory disease in Westernized countries.
Journal ArticleDOI
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
Laurence Macia,Jian Tan,Angélica T. Vieira,Katie Leach,Dragana Stanley,Suzanne Luong,Mikako Maruya,Craig R. M. McKenzie,Atsushi Hijikata,Connie H.Y. Wong,Lauren C. Binge,Alison N. Thorburn,Nina Chevalier,Caroline Ang,Eliana Mariño,Remy Robert,Stefan Offermanns,Mauro M. Teixeira,Robert J. Moore,Richard A. Flavell,Sidonia Fagarasan,Charles R. Mackay +21 more
TL;DR: It is shown that diets deficient or low in fibre exacerbate colitis development, while very high intake of dietary fibre or the SCFA acetate protects against colitis.
Journal ArticleDOI
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
Alison N. Thorburn,Craig R. M. McKenzie,Sj Shen,Dragana Stanley,Laurence Macia,Linda J. Mason,Laura K Roberts,Connie H.Y. Wong,Raymond Shim,Remy Robert,Nina Chevalier,Jian Tan,Eliana Mariño,Robert J. Moore,Lee H. Wong,Malcolm J. McConville,Dedreia Tull,Lisa Wood,Vanessa E. Murphy,Joerg Mattes,Peter G. Gibson,Charles R. Mackay +21 more
TL;DR: It is shown that feeding mice a high-fibre diet yields a distinctive gut microbiota, which increases the levels of the short-chain fatty acid, acetate, which led to marked suppression of allergic airways disease (AAD), by enhancing T-regulatory cell numbers and function.
Journal ArticleDOI
High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.
Francine Z. Marques,Erin M. Nelson,Po-Yin Chu,Duncan Horlock,April Fiedler,Mark Ziemann,Jian Tan,Sanjaya Kuruppu,Niwanthi W. Rajapakse,Assam El-Osta,Charles R. Mackay,David M. Kaye +11 more
TL;DR: A diet high in fiber led to changes in the gut microbiota that played a protective role in the development of cardiovascular disease, and the favorable effects of fiber may be explained by the generation and distribution of one of the main metabolites of the Gut microbiota, the short-chain fatty acid acetate.
Journal ArticleDOI
Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways.
Jian Tan,Craig R. M. McKenzie,Peter Vuillermin,Gera Goverse,Carola G. Vinuesa,Reina E. Mebius,Laurence Macia,Laurence Macia,Charles R. Mackay,Charles R. Mackay +9 more
TL;DR: It is shown that high-fiber feeding in mice improved oral tolerance and protected against food allergy by enhancing retinal dehydrogenase activity in CD103(+) DC, and depended on vitamin A in the diet.