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Deepak Bhattarai
Researcher at University of Kentucky
Publications - 30
Citations - 417
Deepak Bhattarai is an academic researcher from University of Kentucky. The author has contributed to research in topics: Cancer & Antibacterial activity. The author has an hindex of 9, co-authored 29 publications receiving 282 citations. Previous affiliations of Deepak Bhattarai include Korea University of Science and Technology & Dongguk University.
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Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A "structure-activity relationship" perspective.
TL;DR: This review will summarize the structure–activity relationship of ten different chemotypes reported to be HIF‐1 inhibitors in the last decade, their mechanisms of action for Hif‐1 inhibition, progress in the way of target‐specific inhibitors, and problems associated with current inhibitors.
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Recent Advances in the Development of Pharmacologically Active Compounds that Contain a Benzoxazole Scaffold
TL;DR: This focus review, which highlights recent advancements in the development of benzoxazole-based pharmacologically active compounds since the year 2000, highlights the importance of knowing the carrier and removal status of this substance.
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Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors.
Ravi Naik,Misun Won,Hyun Seung Ban,Deepak Bhattarai,Xuezhen Xu,Yumi Eo,Ye Seul Hong,Sarbjit Singh,Yongseok Choi,Hee Chul Ahn,Kyeong Lee +10 more
TL;DR: The inhibitory effect of the probes on HIF-1α activity was consistent with that of theMDH2 enzyme assay, which was further confirmed by the effect on in vitro binding activity to recombinant human MDH2, oxygen consumption, ATP production, and AMP activated protein kinase (AMPK) activation.
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Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration
Shinichi Fukuda,Shinichi Fukuda,Akhil Varshney,Benjamin J. Fowler,Shaobin Wang,Siddharth Narendran,Siddharth Narendran,Kameshwari Ambati,Tetsuhiro Yasuma,Tetsuhiro Yasuma,Joseph Magagnoli,Joseph Magagnoli,Hannah Leung,Shuichiro Hirahara,Shuichiro Hirahara,Yosuke Nagasaka,Reo Yasuma,Reo Yasuma,Ivana Apicella,Felipe Pereira,Felipe Pereira,Ryan D. Makin,Eamonn Magner,Xinan Liu,Jian Sun,Mo Wang,Kirstie Baker,Kenneth M. Marion,Xiwen Huang,Elmira Baghdasaryan,Meenakshi Ambati,Vidya L. Ambati,Akshat Pandey,Lekha Pandya,Tammy H. Cummings,Tammy H. Cummings,Daipayan Banerjee,Peirong Huang,Praveen Yerramothu,Genrich V. Tolstonog,Ulrike Held,Jennifer A. Erwin,Apuã C. M. Paquola,Joseph R. Herdy,Yuichiro Ogura,Hiroko Terasaki,Tetsuro Oshika,Shaban Darwish,Ramendra K. Singh,Saghar Mozaffari,Deepak Bhattarai,Kyung Bo Kim,James W. Hardin,James W. Hardin,Charles L. Bennett,Charles L. Bennett,David R. Hinton,Timothy Hanson,Timothy Hanson,Christian Röver,Keykavous Parang,Nagaraj Kerur,Jinze Liu,Brian C. Werner,S Scott Sutton,S Scott Sutton,Srinivas R. Sadda,Gerald G. Schumann,Bradley D. Gelfand,Fred H. Gage,Jayakrishna Ambati +70 more
TL;DR: In this article, the authors reported that Alu RNA-induced RPE degeneration is mediated via cytoplasmic L1-reverse-transcribed Alu cDNA independently of retrotransposition.
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Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.
Semi Lim,Hye Young Cho,Dae Gyu Kim,Younah Roh,Se Young Son,Ameeq Ul Mushtaq,Minkyoung Kim,Deepak Bhattarai,Aneesh Sivaraman,Youngjin Lee,Jihye Lee,Won Suk Yang,Hoi Kyoung Kim,Myung Hee Kim,Kyeong Lee,Young Ho Jeon,Sunghoon Kim +16 more
TL;DR: The cellular stability of an oncogenic factor, AIMP2-DX2, is increased via association with HSP70, and interference with this interaction by a small-molecule compound promotes ubiquitin-mediated degradation and reduces cancer cell growth.