There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

http://dns2.asia.edu.tw/~ysho/YSHO-English/1000%20WC/PDF/Pro%20Bio34,%20451.pdf

Pseudo-second order model for sorption processes

Peptides or proteins convert under some conditions from their soluble forms into highly ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging from neurodegenerative disorders to systemic amyloidoses. In this review, we identify the diseases known to be associated with formation of fibrillar aggregates and the specific peptides and proteins involved in each case. We describe, in addition, that living organisms can take advantage of the inherent ability of proteins to form such structures to generate novel and diverse biological functions. We review recent advances toward the elucidation of the structures of amyloid fibrils and the mechanisms of their formation at a molecular level. Finally, we discuss the relative importance of the common main-chain and side-chain interactions in determining the propensities of proteins to aggregate and describe some of the evidence that the oligomeric fibril precursors are the primary origins of pathological behavior.

/pdf/protein-misfolding-functional-amyloid-and-human-disease-2w386pwb7k.pdf

Protein Misfolding, Functional Amyloid, and Human Disease

Throughout the biological world, a 30 A hydrophobic film typically delimits the environments that serve as the margin between life and death for individual cells. Biochemical and biophysical findings have provided a detailed model of the composition and structure of membranes, which includes levels of dynamic organization both across the lipid bilayer (lipid asymmetry) and in the lateral dimension (lipid domains) of membranes. How do cells apply anabolic and catabolic enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functionalities of their individual membranes?

/pdf/membrane-lipids-where-they-are-and-how-they-behave-1rycz1l7v8.pdf

Membrane lipids: where they are and how they behave.

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

In this study, the status of T cell-dependent cytokine gene expressions in the acute phase (3-day post-infection and 5-day post-infection) of infection with vaccine virus strains of New castle disease virus (NDV) (R2B and Lasota), Avian infectious bronchitis virus (AIBV) (Massachusetts H120), and Infectious Bursal Disease virus (IBDV) in SPF chicken of seven day age was evaluated. The birds were divided into four groups, each having six birds. Each group of birds was inoculated with the prescribed dose of different vaccines at 7 days of age. Blood was collected before inoculation (uninfected), at the 3rd and 5th day post-inoculation. Presence of virus in peripheral blood confirmed by real-time reverse-transcription PCR assay and quantitation of cytokine was performed in peripheral blood by real time PCR assay. It was observed that the infection with different vaccine strains of viruses in poultry modulates cytokine expression in order to elicit antiviral immune responses. AIBV and NDV viruses markedly up-regulate IL- 2, IL-12, p40, IL-4, IL-5, and IL-13 whereas, IBDV induces prolonged up-regulation of IFN-γ, IL-10 genes.

Cytokine profiling in the acute phase of viral vaccination in Poultry

Comparative Numerical Analysis of Broadband Light Trapping Structures Based on Plasmonic Metals Nanosphere and Silicon Nanopillar Arrays for Thin Solar Cells

Copper Iodide Mediated Telescoped Synthesis of 3-Cyanoimidazo[1,2-a]Pyridines, Photophysical and DFT Studies

Maximizing Interoperability, Enriching EHR Data: Transforming HL7 FHIR Data to RDF Using the FHIR RDF Playground

The crystal structure of the title compound is determined by single crystal X-ray structure analysis. The structure was solved by direct method and refined to a final R-value of 0.0469 for 2826 observed reflections. The benzocoumarin ring system is planar. The central ring of 4-azaphenantrene moiety has a half chair conformation, phenyl substituent forms dihedral angle of 56.46° with the mean plane of 4-azaphenantrene system. The coumarin system is rotated relative to the latter by 15.48(2)°. This orientation is stabilized by two weak intramolecular C–H···N hydrogen bonds.

Deepak Sharma

Papers

Cytokine profiling in the acute phase of viral vaccination in Poultry

Comparative Numerical Analysis of Broadband Light Trapping Structures Based on Plasmonic Metals Nanosphere and Silicon Nanopillar Arrays for Thin Solar Cells

Copper Iodide Mediated Telescoped Synthesis of 3-Cyanoimidazo[1,2-a]Pyridines, Photophysical and DFT Studies

Maximizing Interoperability, Enriching EHR Data: Transforming HL7 FHIR Data to RDF Using the FHIR RDF Playground

Crystal Structure of 3-[1-(4-Methylphenyl)-9,10-dihydro-4-azaphenanthren-3-yl]benzo[f]coumarin