M
Monica J. Justice
Researcher at Baylor College of Medicine
Publications - 139
Citations - 9199
Monica J. Justice is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 47, co-authored 138 publications receiving 8280 citations. Previous affiliations of Monica J. Justice include University of Manchester & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson,Ann M. Flenniken,Xiao Ji,Lydia Teboul,Michael D. Wong,Jacqueline K. White,Terrence F. Meehan,Wolfgang Weninger,Henrik Westerberg,Hibret A. Adissu,Candice N. Baker,Lynette Bower,James M. Brown,L. Brianna Caddle,Francesco Chiani,Dave Clary,James Cleak,Mark J. Daly,James M. Denegre,Brendan Doe,Mary E. Dolan,Sarah M. Edie,Helmut Fuchs,Valerie Gailus-Durner,Antonella Galli,Alessia Gambadoro,Juan Gallegos,Shiying Guo,Neil R. Horner,Chih-Wei Hsu,Sara Johnson,Sowmya Kalaga,Lance C. Keith,Louise Lanoue,Thomas N. Lawson,Monkol Lek,Monkol Lek,Manuel Mark,Susan Marschall,Jeremy Mason,Melissa L. McElwee,Susan Newbigging,Lauryl M. J. Nutter,Kevin A. Peterson,Ramiro Ramirez-Solis,Douglas J. Rowland,Edward Ryder,Kaitlin E. Samocha,Kaitlin E. Samocha,John R. Seavitt,Mohammed Selloum,Zsombor Szoke-Kovacs,Masaru Tamura,Amanda G. Trainor,Ilinca Tudose,Shigeharu Wakana,Jonathan Warren,Olivia Wendling,David B. West,Leeyean Wong,Atsushi Yoshiki,Daniel G. MacArthur,Daniel G. MacArthur,Glauco P. Tocchini-Valentini,Xiang Gao,Paul Flicek,Allan Bradley,William C. Skarnes,Monica J. Justice,Helen Parkinson,Mark W. Moore,Sara Wells,Robert E. Braun,Karen L. Svenson,Martin Hrabé de Angelis,Yann Herault,Timothy J. Mohun,Ann-Marie Mallon,R. Mark Henkelman,Steve D.M. Brown,David J. Adams,Kevin C K Lloyd,Colin McKerlie,Arthur L. Beaudet,Maja Bucan,Stephen A. Murray +85 more
TL;DR: It is shown that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts and reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background.
Journal ArticleDOI
A Twist Code Determines the Onset of Osteoblast Differentiation
Peter Bialek,Britt Kern,Xiangli Yang,Marijke Schrock,Drazen Sosic,Nancy A. Hong,Hua Wu,Kai Yu,David M. Ornitz,Eric N. Olson,Monica J. Justice,Gerard Karsenty +11 more
TL;DR: It is shown that Twist proteins transiently inhibit Runx2 function during skeletogenesis, which means that relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation.
Journal ArticleDOI
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.
TL;DR: Morphological and neural patterning studies indicate a role for the Lp gene product in controlling early morphogenesis and patterning of both axial midline structures and the developing neural plate.
Journal ArticleDOI
Gene defect in ectodermal dysplasia implicates a death domain adapter in development.
Denis J. Headon,Stephanie A. Emmal,Betsy Ferguson,Abigail S. Tucker,Monica J. Justice,Paul T. Sharpe,Jonathan Zonana,Paul A. Overbeek +7 more
TL;DR: The findings show that the death receptor/adapter signalling mechanism is conserved in developmental, as well as apoptotic, signalling.
Journal ArticleDOI
Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice
Jonathan Singer,Annie E. Hill,Lindsay C. Burrage,Keith R. Olszens,Junghan Song,Monica J. Justice,William E. O'Brien,David V. Conti,John S. Witte,Eric S. Lander,Eric S. Lander,Joseph H. Nadeau,Joseph H. Nadeau +12 more
TL;DR: The construction of a complete CSS panel for a vertebrate species shows that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains.