Denise Glaise

TL;DR: A cell line, called HepaRG, is described, which exhibits hepatocyte-like morphology, expresses specific hepatocyte functions, and supports HBV infection as well as primary cultures of normal human hepatocytes, suitable for many applications including drug metabolism studies.

TL;DR: HepaRG cells constitute the first human hepatoma cell line expressing high levels of the major P450s involved in xenobiotic metabolism and represent a reliable surrogate to human hepatocytes for drug metabolism and toxicity studies.

TL;DR: Recent results obtained with a new human hepatoma cell line, named HepaRG, derived from a human hepatocellular carcinoma, which could represent a surrogate to primary human hepatocytes for xenobiotic metabolism and toxicity studies and even more, a unique model system for analysing genotoxic compounds.

TL;DR: The results demonstrate for the first time long-term stabilization and reversibility of a specific function (albumin secretion) at high levels by adult hepatocytes cultured in serum-free medium and suggest that both the presence of other liver cell type(s) and the production of an extracellular matrix are needed for the maintenance of specific functions in cultured hepatocytes.

TL;DR: The results demonstrate the great plasticity of transformed hepatic progenitor cells and suggest that the transdifferentiation process could supply the pool of hepaticprogenitor cells, and highlight possible mechanisms by which trans Differentiation and proliferation of unipotent hepatocytes might cooperate in the development of mixed and differentiated tumors.