Showing papers in "Chemico-Biological Interactions in 2007"

TL;DR: Recent results obtained with a new human hepatoma cell line, named HepaRG, derived from a human hepatocellular carcinoma, which could represent a surrogate to primary human hepatocytes for xenobiotic metabolism and toxicity studies and even more, a unique model system for analysing genotoxic compounds.

TL;DR: These hepatic cellular models are apparently suitable to experimentally investigate the impact of fat overaccumulation in the liver excluding other factors that could influence hepatocyte behaviour.

TL;DR: Overallbutadiene capacity is determined by ethylene cracker operating rates, the type of feed being cracked, and availability of butadiene extraction capacity, which is dependent on the composition of the feed to the cracking unit.

TL;DR: Findings suggest that M. koenigii treatment exerts a therapeutic protective nature in diabetes by decreasing oxidative stress and pancreatic beta-cell damage.

TL;DR: 1,2,3,4,6-Pentagalloylglucose was found to be more effective to scavenge DPPH* radical and protect against lipid peroxidation and induced a decrease in the expression of 11 transcripts related to antioxidant enzymes family and DNA repair.

TL;DR: The results suggest that temperature variation does alter the active oxygen metabolism by modulating antioxidant enzyme activities, which can be used as biomarker to detect sublethal effects of pollution.

TL;DR: In conclusion, human hepatocytes represent a critical experimental model for drug development, allowing early evaluation of human drug properties to guide the design and selection of drug candidates with a high probability of clinical success.

TL;DR: This review promotes the value of isolated hepatocytes in modern Drug Discovery programmes and outlines how increased understanding, particularly in the area of in vitro-in vivo extrapolation (IVIVE), has led to more widespread use.

TL;DR: It was shown that dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes mellitus and the catechin components of green tea have been shown to possess anti-carcinogenic properties possibly related to their anti-oxidant activity.

TL;DR: It is reasonable to consider that the variability observed in human hepatocytes reflects the existing phenotypic heterogeneity of the P450 expression in human liver, as a major determinant of drug clearance and interindividual pharmacokinetic differences.

TL;DR: The importance of designing Zn-containing bioactive glasses without cytotoxic effects is highlighted and supplementary information about the prooxidant role of zinc in living systems is given.

TL;DR: Embelin can act as a competitive antioxidant in physiological conditions, according to kinetics and mechanism of the reactions of embelin with hydroxyl, one-electron oxidizing, organo-haloperoxyl and thiyl radicals.

TL;DR: A good correlation between the above cellular effects of sage and the effects of their main phenolic compounds was found, which indicates an improvement of the antioxidant potential of the cells.

TL;DR: The results suggest that cadmium induces an oxidation of cellular lipids and proteins and that administration of α-tocopherol can reduce Cd-induced oxidative stress and improve the glutathione level together with other biochemical parameters.

TL;DR: Results showed that HSE induced cytotoxicity and apoptosis of AGS cells in a concentration-dependent manner but is ineffective in Chang liver cells, and suggested that H SE mediated AGS apoptosis via the JNK/p38 signaling cascade.

TL;DR: It could be concluded that T. arjuna acts as an gastroprotective agent probably due to its free radical scavenging activity and cytoprotective nature.

TL;DR: The results indicate that the protection of some antioxidant mechanisms and the inhibition of some oxidant mechanisms have a role in AR-1's antiulcer effect mechanism.

TL;DR: The generation of 8-oxodG in cells exposed to casIIgly suggests that the generation of ROS is the major cause of the cytotoxicity observed and underlies the high toxicity and anticancer activity of these compounds.

TL;DR: Flavanones richly exist in citrus and have been well characterized to have various bioactive properties and perturb the invasion and metastasis of lung cancer cells, thereby constituting an adjuvant treatment for metastasis control.

TL;DR: Results showed that both n-6PUFAs and n-3 PUFAs decrease human lung-tumor cell growth in a concentration-dependent manner, inducing cell death mainly evident at 100microM concentration.

TL;DR: The results of the present work suggest that the natural compound arzanol exerts useful antioxidant properties in different in vitro systems of lipid peroxidation.

TL;DR: It was observed that ethanolic leaf extract of C. fistula Linn protects the liver against DEN induced hepatic injury in rats and induction of oxidative stress in the liver was evidenced by increased LPO and fall in the activities of SOD and CAT.

TL;DR: Oral administration of MEOT remarkably reduced the lipid peroxidation activity and increased the antioxidants level in drug treated animals and decreased the tumour weight significantly (P<0.05) in the DMBA+MEOT groups.

TL;DR: The study suggests that administration of MiADMSA is generally a better lead chelator than DMSA while combined administration of DMSA and MiadMSA might be a better treatment option compared to monotherapy at least in the removal of lead from the target tissues.

TL;DR: A mathematical spatial-temporal model of the liver lobule regenerating after CCl(4) intoxication suggests that the ability of hepatocytes to realign after cell division by a process of coordinated cell orientation in combination with cell polarity may be at least as critical as hepatocyte proliferation itself.

TL;DR: Results indicate that the treatment with Star reduces the tumor burden, lowers oxidative stress and increases the level of phase II enzymes, which may contribute to its anti-carcinogenic potential.

TL;DR: The present results support the presence of a causal relationship between high cumulative exposure and high intensity of exposure to 1,3-butadiene (BD) and leukemia.

TL;DR: The results suggest that the rate of metabolism of B[a]P and type of reactive metabolites formed influence the resulting balance of pro-APoptotic and anti-apoptotic cell signaling, and hence the mechanisms involved in cell death and the chances of more permanent genetic damage.

TL;DR: Experimental results suggest that AA protects arsenic-induced cytotoxicity in murine hepatocytes, and the cytoprotective activity of AA was found to be comparable to that of a known antioxidant, vitamin C.

TL;DR: There is general consensus that studies using human hepatocyte cultures currently provide the best indication of the in vivo induction potential of NCEs, and the assessment of in vitro induction data from the literature suggest that the two-fold induction threshold and the percent of positive control criteria may not be the best methods to accurately assess theIn vivo induction Potential of a drug.