Denise Guetard

TL;DR: Preincubation of T4+ lymphocytes with three individual monoclonal antibodies directed at the T4 glycoprotein blocked cell infection by LAV, strongly support the view that a surface molecule directly involved in cellular functions acts as, or is related to, the receptor for a human retrovirus.

TL;DR: It is established that this new retrovirus, here referred to as LAV-II, is distantly related to LAV and distinct from STLV-IIImac, suggesting that the West African AIDS virus may be more closely related to this simian virus than toLAV.

TL;DR: It is shown here that the central DNA flap acts as a cis-determinant of HIV-1 DNA nuclear import, which can be corrected to wild-type levels by reinsertion of the DNA flap sequence.

TL;DR: The molecular cloning of the complete 9.5-kilobase (kb) genome of HIV-2 is reported, the observation of restriction site polymorphism between different isolates, and a preliminary analysis of the relationship ofAIDS-2 with other human and simian retroviruses is analyzed.

TL;DR: A strain of lymphadenopathy associated retrovirus passaged in vitro was used to infect a lymphoblastoid cell line obtained by transformation with Epstein-Barr virus of B lymphocytes from a healthy donor, and this adapted strain retained the biochemical, ultrastructural, and antigenic characteristics of the original strain.