Dennis Vitkup

TL;DR: The method of minimization of metabolic adjustment (MOMA), whereby the hypothesis that knockout metabolic fluxes undergo a minimal redistribution with respect to the flux configuration of the wild type is tested, is tested and found to be useful in understanding the evolutionary optimization of metabolism.

TL;DR: This study uses NETBAG to identify a large biological network of genes affected by rare de novo CNVs in autism, which is strongly related to genes previously implicated in autism and intellectual disability phenotypes.

TL;DR: In this article, the authors argue that tissue of origin is an important determinant of how cancers satisfy their metabolic requirements, and that tissue context defines cancer dependence on specific metabolic pathways is unknown, but despite the same initiating events, these tumors use branched chain amino acids (BCAAs) differently.

TL;DR: A novel molecular dynamics simulation procedure with the protein and solvent at different temperatures has been used, showing the essential role of solvent in controlling functionally important protein fluctuations above 180 K.

TL;DR: This work evaluates different strategies for optimizing information return on effort and concludes that the strategy that maximizes structural coverage requires about seven times fewer structure determinations compared with the strategy in which targets are selected at random.