C
Christopher R. Chin
Researcher at Cornell University
Publications - 58
Citations - 4671
Christopher R. Chin is an academic researcher from Cornell University. The author has contributed to research in topics: Viral replication & Influenza A virus. The author has an hindex of 21, co-authored 47 publications receiving 3562 citations. Previous affiliations of Christopher R. Chin include Massachusetts Institute of Technology & Ragon Institute of MGH, MIT and Harvard.
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Journal ArticleDOI
IFITM3 restricts the morbidity and mortality associated with influenza
Aaron R. Everitt,Simon Clare,Thomas Pertel,Sinu P. John,Rachael S. Wash,Sarah E. Smith,Christopher R. Chin,Eric M. Feeley,Jennifer S. Sims,David J. Adams,Helen M. Wise,Leanne Kane,David Goulding,Paul Digard,Verneri Anttila,J Kenneth Baillie,Timothy S. Walsh,David A. Hume,Aarno Palotie,Yali Xue,Vincenza Colonna,Vincenza Colonna,Chris Tyler-Smith,Jake Dunning,Stephen B. Gordon,Rosalind L. Smyth,Peter J. M. Openshaw,Gordon Dougan,Abraham L. Brass,Abraham L. Brass,Paul Kellam,Paul Kellam +31 more
TL;DR: Data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans.
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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
Shawn M. Davidson,Shawn M. Davidson,Thales Papagiannakopoulos,Benjamin A. Olenchock,Benjamin A. Olenchock,Benjamin A. Olenchock,Julia E. Heyman,Mark A. Keibler,Alba Luengo,Matthew R. Bauer,Abhishek K. Jha,James P. O’Brien,Kerry A. Pierce,Dan Y. Gui,Lucas B. Sullivan,Thomas M. Wasylenko,Lakshmipriya Subbaraj,Christopher R. Chin,Gregory Stephanopolous,Bryan T. Mott,Tyler Jacks,Clary B. Clish,Matthew G. Vander Heiden +22 more
TL;DR: The data suggest that understanding nutrient utilization by tumors can predict metabolic dependencies of cancers in vivo and argue that the in vivo environment is an important determinant of the metabolic phenotype of cancer cells.
Journal ArticleDOI
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Jared R. Mayers,Margaret E. Torrence,Laura V. Danai,Thales Papagiannakopoulos,Shawn M. Davidson,Matthew R. Bauer,Allison N. Lau,Brian W. Ji,Purushottam D. Dixit,Aaron M. Hosios,Alexander Muir,Christopher R. Chin,Elizaveta Freinkman,Tyler Jacks,Brian M. Wolpin,Dennis Vitkup,Matthew G. Vander Heiden +16 more
TL;DR: In this article, the authors argue that tissue of origin is an important determinant of how cancers satisfy their metabolic requirements, and that tissue context defines cancer dependence on specific metabolic pathways is unknown, but despite the same initiating events, these tumors use branched chain amino acids (BCAAs) differently.
Journal ArticleDOI
IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry
Eric M. Feeley,Jennifer S. Sims,Sinu P. John,Christopher R. Chin,Thomas Pertel,Li-Mei Chen,Gaurav D. Gaiha,Bethany J. Ryan,Ruben O. Donis,Stephen J. Elledge,Stephen J. Elledge,Abraham L. Brass,Abraham L. Brass +12 more
TL;DR: It is reported that IFN prevents emergence of viral genomes from the endosomal pathway, and that IFITM3 is both necessary and sufficient for this function.
Journal ArticleDOI
IFITM3 Restricts Influenza A Virus Entry by Blocking the Formation of Fusion Pores following Virus-Endosome Hemifusion
Tanay M. Desai,Mariana Marin,Christopher R. Chin,George Savidis,Abraham L. Brass,Gregory B. Melikyan +5 more
TL;DR: It is proposed that IFITM3 interferes with pore formation either directly, through partitioning into the cytoplasmic leaflet of a hemifusion intermediate, or indirectly, by modulating the lipid/protein composition of this leaflet.