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Brian M. Wolpin
Researcher at Harvard University
Publications - 305
Citations - 21474
Brian M. Wolpin is an academic researcher from Harvard University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 67, co-authored 257 publications receiving 16470 citations. Previous affiliations of Brian M. Wolpin include Yale University & Brigham and Women's Hospital.
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Journal ArticleDOI
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Vasanthi S. Viswanathan,Matthew J. Ryan,Harshil Dhruv,Shubhroz Gill,Ossia M. Eichhoff,Brinton Seashore-Ludlow,Samuel D. Kaffenberger,John K. Eaton,Kenichi Shimada,Andrew J. Aguirre,Andrew J. Aguirre,Srinivas R. Viswanathan,Srinivas R. Viswanathan,Shrikanta Chattopadhyay,Pablo Tamayo,Pablo Tamayo,Wan Seok Yang,Matthew G. Rees,Sixun Chen,Zarko V. Boskovic,Sarah Javaid,Cherrie Huang,Xiaoyun Wu,Yuen-Yi Tseng,Elisabeth Roider,Dong Gao,James M. Cleary,Brian M. Wolpin,Jill P. Mesirov,Jill P. Mesirov,Daniel A. Haber,Daniel A. Haber,Jeffrey A. Engelman,Jesse S. Boehm,Joanne Kotz,Cindy S. Hon,Yu Chen,William C. Hahn,William C. Hahn,Mitchell P. Levesque,John G. Doench,Michael E. Berens,Alykhan F. Shamji,Paul A. Clemons,Brent R. Stockwell,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber +47 more
TL;DR: Vulnerability to ferroptic cell death induced by inhibition of a lipid peroxidase pathway as a feature of therapy-resistant cancer cells across diverse mesenchymal cell-state contexts is identified.
Journal ArticleDOI
Pancreatic adenocarcinoma, version 2.2017: Clinical practice guidelines in Oncology
Margaret A. Tempero,Mokenge P. Malafa,Mahmoud M. Al-Hawary,Horacio J. Asbun,Andrew Bain,Stephen W. Behrman,Al B. Benson,Ellen F. Binder,Dana Backlund Cardin,Charles Cha,E. Gabriela Chiorean,Vincent Chung,Brian G. Czito,Mary Dillhoff,Efrat Dotan,Cristina R. Ferrone,Jeffrey M. Hardacre,William G. Hawkins,Joseph M. Herman,Andrew H. Ko,Srinadh Komanduri,Albert C. Koong,Noelle K. LoConte,Andrew M. Lowy,Cassadie Moravek,Eric K. Nakakura,Eileen M. O'Reilly,Jorge Obando,Sushanth Reddy,Courtney L. Scaife,Sarah P. Thayer,Colin D. Weekes,Robert A. Wolff,Brian M. Wolpin,Jennifer L. Burns,Susan Darlow +35 more
TL;DR: The NCCN Guidelines for Pancreatic Adenocarcinoma focus on diagnosis and treatment with systemic therapy, radiation therapy, and surgical resection, as well as on management of locally advanced unresectable and metastatic disease.
Journal ArticleDOI
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
Hervé Tiriac,Pascal Belleau,Dannielle D. Engle,Dennis Plenker,Astrid Deschênes,Tim D.D. Somerville,Fieke E. M. Froeling,Richard A. Burkhart,Robert E. Denroche,Gun-Ho Jang,Koji Miyabayashi,C. Megan Young,C. Megan Young,Hardik Patel,Michelle Ma,Joseph F. LaComb,Randze Lerie Palmaira,Ammar A. Javed,Jasmine Huynh,Molly E. Johnson,Kanika Arora,Nicolas Robine,Minita Shah,Rashesh Sanghvi,Austin Goetz,Cinthya Y. Lowder,Laura A. Martello,Else Driehuis,Nicolas Lecomte,Gokce Askan,Christine A. Iacobuzio-Donahue,Hans Clevers,Laura D. Wood,Ralph H. Hruban,Elizabeth D. Thompson,Andrew J. Aguirre,Brian M. Wolpin,Aaron R. Sasson,Joseph Kim,Maoxin Wu,Juan Carlos Bucobo,Peter J. Allen,Divyesh V. Sejpal,William Nealon,James Sullivan,Jordan M. Winter,Phyllis A. Gimotty,Jean L. Grem,Dominick J. DiMaio,Jonathan M. Buscaglia,Paul M. Grandgenett,Jonathan R. Brody,Michael A. Hollingsworth,Grainne M. O'Kane,Faiyaz Notta,Edward J. Kim,James M. Crawford,Craig Devoe,Allyson J. Ocean,Christopher L. Wolfgang,Kenneth H. Yu,Ellen Li,Christopher R. Vakoc,Benjamin Hubert,Sandra Fischer,Sandra Fischer,Julie M. Wilson,Richard A. Moffitt,Jennifer J. Knox,Alexander Krasnitz,Steven Gallinger,Steven Gallinger,Steven Gallinger,David A. Tuveson +73 more
TL;DR: A pancreatic cancer patient-derived organoid (PDO) library is generated that recapitulates the mutational spectrum and transcriptional subtypes of primary Pancreatic cancer and proposes that combined molecular and therapeutic profiling of PDOs may predict clinical response and enable prospective therapeutic selection.
Journal ArticleDOI
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
Laufey T. Amundadottir,Peter Kraft,Rachael Z. Stolzenberg-Solomon,Charles S. Fuchs,Gloria M. Petersen,Alan A. Arslan,H. Bas Bueno-de-Mesquita,Myron D. Gross,Kathy J. Helzlsouer,Eric J. Jacobs,Andrea Z. LaCroix,Wei Zheng,Demetrius Albanes,William R. Bamlet,Christine D. Berg,Franco Berrino,Sheila Bingham,Julie E. Buring,Paige M. Bracci,Federico Canzian,Françoise Clavel-Chapelon,Sandra Clipp,Michelle Cotterchio,Mariza de Andrade,Eric J. Duell,John W. Fox,Steven Gallinger,J. Michael Gaziano,J. Michael Gaziano,Edward Giovannucci,Michael Goggins,Carlos A. González,Göran Hallmans,Susan E. Hankinson,Manal Hassan,Elizabeth A. Holly,David J. Hunter,Amy K. Hutchinson,Amy K. Hutchinson,Rebecca D. Jackson,Kevin B. Jacobs,Kevin B. Jacobs,Mazda Jenab,Rudolf Kaaks,Alison P. Klein,Charles Kooperberg,Robert C. Kurtz,Donghui Li,Shannon M. Lynch,Margaret T. Mandelson,Margaret T. Mandelson,Robert R. McWilliams,Julie B. Mendelsohn,Dominique S. Michaud,Dominique S. Michaud,Sara H. Olson,Kim Overvad,Alpa V. Patel,Petra H.M. Peeters,Petra H.M. Peeters,Aleksandar Rajkovic,Elio Riboli,Harvey A. Risch,Xiao-Ou Shu,Gilles Thomas,Geoffrey S. Tobias,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Stephen K. Van Den Eeden,Jarmo Virtamo,Jean Wactawski-Wende,Brian M. Wolpin,Herbert Yu,Kai Yu,Anne Zeleniuch-Jacquotte,Stephen J. Chanock,Patricia Hartge,Robert N. Hoover +77 more
TL;DR: In this paper, a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide, was conducted, where 558,542 SNPs were genotyped in 1,896 individuals and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study.
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
Laufey T. Amundadottir,Peter Kraft,Rachael Z. Stolzenberg-Solomon,Charles S. Fuchs,Gloria M. Petersen,Alan A. Arslan,H. Bas Bueno-de-Mesquita,Myron D. Gross,Kathy J. Helzlsouer,Eric J. Jacobs,Andrea Z. LaCroix,Wei Zheng,Demetrius Albanes,William R. Bamlet,Christine D. Berg,Franco Berrino,Sheila Bingham,Julie E. Buring,Paige M. Bracci,Federico Canzian,Françoise Clavel-Chapelon,Sandra Clipp,Michelle Cotterchio,Mariza de Andrade,Eric J. Duell,John W. Fox,Steven Gallinger,J. Michael Gaziano,J. Michael Gaziano,Edward Giovannucci,Michael Goggins,Carlos A. González,Göran Hallmans,Susan E. Hankinson,Manal Hassan,Elizabeth A. Holly,David J. Hunter,Amy K. Hutchinson,Amy K. Hutchinson,Rebecca D. Jackson,Kevin B. Jacobs,Kevin B. Jacobs,Mazda Jenab,Rudolf Kaaks,Alison P. Klein,Charles Kooperberg,Robert C. Kurtz,Donghui Li,Shannon M. Lynch,Margaret T. Mandelson,Margaret T. Mandelson,Robert R. McWilliams,Julie B. Mendelsohn,Dominique S. Michaud,Dominique S. Michaud,Sara H. Olson,Kim Overvad,Alpa V. Patel,Petra H.M. Peeters,Petra H.M. Peeters,Aleksandar Rajkovic,Elio Riboli,Harvey A. Risch,Xiao-Ou Shu,Gilles Thomas,Geoffrey S. Tobias,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Stephen K. Van Den Eeden,Jarmo Virtamo,Jean Wactawski-Wende,Brian M. Wolpin,Herbert Yu,Kai Yu,Anne Zeleniuch-Jacquotte,Stephen J. Chanock,Patricia Hartge,Robert N. Hoover +77 more
TL;DR: An association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 is identified, consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreaticcancer than those with groups A or B.