Jared R. Mayers

TL;DR: It is demonstrated that adipose tissue uses lipokines such as C16:1n7-palmitoleate to communicate with distant organs and regulate systemic metabolic homeostasis and a lipid-mediated endocrine network is revealed.

TL;DR: It is suggested that increased whole-body protein breakdown is an early event in development of PDAC, and elevated plasma levels of branched-chain amino acids (BCAAs) are associated with a greater than twofold increased risk of future pancreatic cancer diagnosis.

TL;DR: It is shown that mitigation of ER stress with a chemical chaperone results in marked protection against lipotoxic death in macrophages and prevents macrophage fatty acid–binding protein-4 (aP2) expression and that ER responses can be modified, genetically or chemically, to protect the organism against the deleterious effects of hyperlipidemia.

TL;DR: In this article, the authors argue that tissue of origin is an important determinant of how cancers satisfy their metabolic requirements, and that tissue context defines cancer dependence on specific metabolic pathways is unknown, but despite the same initiating events, these tumors use branched chain amino acids (BCAAs) differently.

TL;DR: It is demonstrated that reductive glutamine metabolism is initiated in response to perturbations that result in an increase in the α-ketoglutarate/citrate ratio, which might require distinct modulations of metabolite concentrations rather than targeting the upstream signalling.