D
Dennis W. Choi
Researcher at Stony Brook University
Publications - 247
Citations - 51780
Dennis W. Choi is an academic researcher from Stony Brook University. The author has contributed to research in topics: Glutamate receptor & NMDA receptor. The author has an hindex of 99, co-authored 243 publications receiving 50284 citations. Previous affiliations of Dennis W. Choi include Merck & Co. & Stanford University.
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Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons.
TL;DR: If further studies establish that DX and related compounds retain neuron-protective efficacy in appropriate animal models, the established clinical safety record of DX and dextromethorphan may allow prompt investigation of the NMDA receptor-blockade strategy in certain neurological disease states.
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Differences in Vulnerability to Permanent Focal Cerebral Ischemia Among 3 Common Mouse Strains
Arshad Majid,Yong Y. He,Jeffrey M. Gidday,Stuart S. Kaplan,Ernesto R. Gonzales,Tae Sung Park,Joseph D. Fenstermacher,Ling Wei,Dennis W. Choi,Chung Y. Hsu +9 more
TL;DR: The presence and patency of posterior communicating arteries, although variable among strains, did not affect preischemic or postISChemic cortical blood flow or bear any relationship to ischemic injury, highlighting the importance of selecting genetically matched wild-type controls.
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Measuring social communication behaviors as a treatment endpoint in individuals with autism spectrum disorder
Evdokia Anagnostou,Nancy E. Jones,Marisela Huerta,Alycia K. Halladay,Paul P. Wang,Lawrence Scahill,Joseph P. Horrigan,Connie Kasari,Catherine Lord,Dennis W. Choi,Katherine J. Sullivan,Geraldine Dawson +11 more
TL;DR: The relative strengths and weaknesses of existing social communication measures for use in clinical trials are discussed and specific areas in need of further development are identified.
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Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death.
TL;DR: The data support the idea that brain caspases mediate the apoptotic component of oxygen-glucose deprivation-induced neuronal death and raise the possibility that combining caspase inhibitors with glutamate antagonists might attenuate brain damage induced by hypoxic-ischemic insults in vivo.
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Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize in brain slices
TL;DR: DM is a widely available, orally effective drug with low toxicity in antitussive doses, which has antiepileptic and NMDA-antagonist properties in vitro and should be expeditiously examined in clinical trials.