D
Dennis W. Choi
Researcher at Stony Brook University
Publications - 247
Citations - 51780
Dennis W. Choi is an academic researcher from Stony Brook University. The author has contributed to research in topics: Glutamate receptor & NMDA receptor. The author has an hindex of 99, co-authored 243 publications receiving 50284 citations. Previous affiliations of Dennis W. Choi include Merck & Co. & Stanford University.
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Journal ArticleDOI
Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose
TL;DR: Observations support the idea that combined NMDA and non-NMDA receptor blockade may have value in ameliorating the neuronal loss associated with prolonged ischemic insults in vivo.
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Glucose deprivation neuronal injury in cortical culture.
TL;DR: Observations support the hypothesis that glucose deprivation-induced cortical neuronal injury is largely mediated by NMDA receptors, and suggest that cell culture methodology can be useful in the quantitative characterization of that injury.
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3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons.
Maria I. Behrens,Jae Koh,Lorella M.T. Canzoniero,Stefano L. Sensi,Cynthia A. Csernansky,Dennis W. Choi +5 more
TL;DR: The results do not exclude that 3-NPA can induce excitotoxicity in more intact systems, but raise the additional possibility that 3,NPA may also act to induce neuronal apoptosis.
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Interferon-γ and interleukin-1β induce nitric oxide formation from primary mouse astrocytes
TL;DR: It is demonstrated by immunoprecipitation and nitrite formation that interleukin-1β plus interferon-γ plus interFγ induce the expression of nitric oxide synthase in primary cultures of murine cortical astrocytes.
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Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity
Pat Manzerra,M. Margarita Behrens,Lorella M.T. Canzoniero,Xue Qing Wang,Valérie Heidinger,Tomomi Ichinose,Shan Ping Yu,Dennis W. Choi +7 more
TL;DR: The observations suggest that the effect of synaptically released zinc on neuronal NMDA receptors may be biphasic: acute block, followed by Src family kinase-mediated up-regulation of NMDA receptor activity and cytotoxicity.