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William F. Danielson
Researcher at Pacific Northwest National Laboratory
Publications - 17
Citations - 849
William F. Danielson is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Mass spectrometry & Ion-mobility spectrometry. The author has an hindex of 13, co-authored 17 publications receiving 755 citations. Previous affiliations of William F. Danielson include Environmental Molecular Sciences Laboratory.
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Journal ArticleDOI
An LC-IMS-MS platform providing increased dynamic range for high-throughput proteomic studies
Erin S. Baker,Eric A. Livesay,Daniel J. Orton,Ronald J. Moore,William F. Danielson,David C. Prior,Yehia M. Ibrahim,Brian L. LaMarche,Anoop Mayampurath,Athena A. Schepmoes,Derek F. Hopkins,Keqi Tang,Richard D. Smith,Mikhail E. Belov +13 more
TL;DR: The LC-IMS-TOF MS system enabled drift time separation of the low concentration spiked peptides from the high concentration mouse peptide matrix components, reducing signal interference and background, and allowing species to be resolved that would otherwise be obscured by other components.
Journal ArticleDOI
Enhanced Ion Utilization Efficiency Using an Electrodynamic Ion Funnel Trap as an Injection Mechanism for Ion Mobility Spectrometry
Brian H. Clowers,Yehia M. Ibrahim,David C. Prior,William F. Danielson,Mikhail E. Belov,Richard D. Smith +5 more
TL;DR: Using a modified electrodynamic ion funnel, the ability to accumulate, store, and eject ions in conjunction with ion mobility spectrometry (IMS), which elevated the charge density of the ion packets ejected from the ion funnel trap (IFT) and provided a considerable increase in the overall ion utilization efficiency of the IMS instrument.
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High-Resolution Differential Ion Mobility Separations Using Helium-Rich Gases
TL;DR: The use of gas mixtures comprising up to 75% He dramatically increases the FAIMS separation capability, with the resolving power for peptides and peak capacity for protein digests reaching and exceeding 100 and resolution gains extend to small molecules, where previously unresolved isomers can now be separated.
Journal ArticleDOI
Development of a new ion mobility time-of-flight mass spectrometer
Yehia M. Ibrahim,Erin S. Baker,William F. Danielson,Randolph V. Norheim,David C. Prior,Gordon A. Anderson,Mikhail E. Belov,Richard D. Smith +7 more
TL;DR: In this article, a new ion mobility spectrometer (IMS) platform was developed to improve upon the sensitivity and reproducibility of previous platforms, and further enhance IMS-MS utility for broad 'panomics' measurements.
Journal ArticleDOI
High-definition differential ion mobility spectrometry with resolving power up to 500.
Alexandre A. Shvartsburg,Thomas A. Seim,William F. Danielson,Randolph V. Norheim,Ronald J. Moore,Gordon A. Anderson,Richard D. Smith +6 more
TL;DR: A new high-definition generator for FAIMS compensation voltage reported here provides a stable and accurate output than can be scanned with negligible steps, which reduces the spectral drift and peak width, thus improving the resolving power and resolution.