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Brian L. LaMarche
Researcher at Pacific Northwest National Laboratory
Publications - 23
Citations - 822
Brian L. LaMarche is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Mass spectrometry & Ion-mobility spectrometry. The author has an hindex of 13, co-authored 23 publications receiving 748 citations. Previous affiliations of Brian L. LaMarche include Environmental Molecular Sciences Laboratory.
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Journal ArticleDOI
Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses.
Eric A. Livesay,Keqi Tang,Beverley K. Taylor,Michael A. Buschbach,Derek F. Hopkins,Brian L. LaMarche,Rui Zhao,Yufeng Shen,Daniel J. Orton,Ronald J. Moore,Ryan T. Kelly,Harold R. Udseth,Richard D. Smith +12 more
TL;DR: This system performs multiple LC separations in parallel, but staggers each of them such that the data-rich region of each separation is sampled sequentially, which maximizes the use of the mass spectrometer.
Journal ArticleDOI
An LC-IMS-MS platform providing increased dynamic range for high-throughput proteomic studies
Erin S. Baker,Eric A. Livesay,Daniel J. Orton,Ronald J. Moore,William F. Danielson,David C. Prior,Yehia M. Ibrahim,Brian L. LaMarche,Anoop Mayampurath,Athena A. Schepmoes,Derek F. Hopkins,Keqi Tang,Richard D. Smith,Mikhail E. Belov +13 more
TL;DR: The LC-IMS-TOF MS system enabled drift time separation of the low concentration spiked peptides from the high concentration mouse peptide matrix components, reducing signal interference and background, and allowing species to be resolved that would otherwise be obscured by other components.
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Experimental Evaluation and Optimization of Structures for Lossless Ion Manipulations for Ion Mobility Spectrometry with Time-of-Flight Mass Spectrometry
Ian K. Webb,Sandilya V. B. Garimella,Aleksey V. Tolmachev,Tsung-Chi Chen,Xinyu Zhang,Randolph V. Norheim,Spencer A. Prost,Brian L. LaMarche,Gordon A. Anderson,Yehia M. Ibrahim,Richard D. Smith +10 more
TL;DR: Both geometries provide IMS resolving powers at the theoretical limit (R ∼ 58) showing that degraded resolution from a “racetrack” effect from turning around a corner can be successfully avoided, and the capability also was maintained for essentially lossless ion transmission.
Journal ArticleDOI
Analytical Characterization of the Electrospray Ion Source in the Nanoflow Regime
TL;DR: The pulsating regime consistently provided better ESI-MS performance than the cone-jet regime for the interface and experimental conditions studied, and approaches for improving MS interface performance for low-flow (nano- to micro-) electrosprays are suggested.
Journal ArticleDOI
A cabled acoustic telemetry system for detecting and tracking juvenile salmon: part 2. Three-dimensional tracking and passage outcomes.
Z. Daniel Deng,Mark A. Weiland,Tao Fu,Tom A. Seim,Brian L. LaMarche,Eric Y. Choi,Thomas J. Carlson,M. Brad Eppard +7 more
TL;DR: How the JSATS cabled system was employed as a reference sensor network for detecting and tracking juvenile salmon and detection and tracking probabilities of fish tagged with JSATS acoustic transmitters are described.