Derek L. Buhl

TL;DR: Sharp wave-associated fast-field oscillations did not begin to emerge until the end of the second postnatal week and showed a gradual increase until day 18, when ripples emerged, and the intra-ripple frequency assumed adult values.

TL;DR: X-ray crystallography shows that EVT-101, a GluN2B antagonist structurally unrelated to the classic phenylethanolamine pharmacophore, binds at the same GLUN1/GluN 2B dimer interface as ifenprodil but adopts a remarkably different binding mode involving a distinct subcavity and receptor interactions.

TL;DR: Novel three-dimensional reconstructions and numerical analyses for studying the spatial organization of four major basal forebrain cell populations, the cholinergic, parvalbumin, calbindin and calretinin containing neurons in the rat suggest that the distribution of these four cell populations is not random but displays a general pattern of association.

TL;DR: In this paper, a transgenic mouse was created in which output of old GCs was specifically inhibited while leaving a substantial portion of young GCs intact, and these mutant mice exhibited deficits in rapid pattern completion.

TL;DR: A novel hypermotivation phenotype that is unique to the rat model of Shank2 dysfunction is shown, in addition to the traditional hyperactive and repetitive behaviors observed in mouse models, which should be explored further as a targetable mechanism for impairment in ASD.