T
Thomas J. McHugh
Researcher at RIKEN Brain Science Institute
Publications - 103
Citations - 7968
Thomas J. McHugh is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Hippocampal formation & Hippocampus. The author has an hindex of 35, co-authored 91 publications receiving 6216 citations. Previous affiliations of Thomas J. McHugh include Massachusetts Institute of Technology & Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network
Thomas J. McHugh,Matt Jones,Matt Jones,Jennifer J. Quinn,Jennifer J. Quinn,Nina Balthasar,Nina Balthasar,Roberto Coppari,Roberto Coppari,Joel K. Elmquist,Bradford B. Lowell,Michael S. Fanselow,Matthew A. Wilson,Susumu Tonegawa +13 more
TL;DR: Evidence is provided that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation, by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1 in dentates gyrus granule Cells.
Journal ArticleDOI
Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics
Shuo Chen,Adam Z. Weitemier,Xiao Zeng,Linmeng He,Xiyu Wang,Yanqiu Tao,Arthur J Huang,Yuki Hashimotodani,Masanobu Kano,Hirohide Iwasaki,Laxmi Kumar Parajuli,Shigeo Okabe,Daniel Boon Loong Teh,Angelo H. All,Iku Tsutsui-Kimura,Kenji F. Tanaka,Xiaogang Liu,Xiaogang Liu,Thomas J. McHugh,Thomas J. McHugh +19 more
TL;DR: It is demonstrated that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons and evoked dopamine release from genetically tagged neurons in the ventral tegmental area and triggered memory recall.
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Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion
Toshiaki Nakashiba,Jesse D. Cushman,Kenneth A. Pelkey,Sophie Renaudineau,Derek L. Buhl,Thomas J. McHugh,Vanessa Rodriguez Barrera,Ramesh Chittajallu,Keisuke S. Iwamoto,Chris J. McBain,Michael S. Fanselow,Susumu Tonegawa +11 more
TL;DR: It is suggested that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion, and older GCs contribute to the rapid recall by pattern completion.
Journal ArticleDOI
Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice
TL;DR: It is found that although the CA1 pyramidal cells of these mice retain place-related activity, there is a significant decrease in the spatial specificity of individual place fields.
Journal ArticleDOI
NMDA receptors, place cells and hippocampal spatial memory.
Kazu Nakazawa,Thomas J. McHugh,Thomas J. McHugh,Matthew A. Wilson,Susumu Tonegawa,Susumu Tonegawa +5 more
TL;DR: The data that have emerged from in vivo hippocampal recording studies that indicate that the activity of hippocampal place cells during behaviour is an expression of a memory trace are discussed.