Di Nie

TL;DR: CCM@LM, a yolk-shell NP with a mesoporous silica nanoparticle (MSN)-supported PEGylated liposome yolk and CCM coating, was developed for chemotherapy and exhibited a homologous tumor-targeting effect.

TL;DR: CCM-coated nanorods (CRs) exhibited improved immune escape ability, rapid extracellular matrix penetration, and enhanced tumor accumulation, further contributing to the enhanced antitumor efficacy, suggesting the significance of shape design in improving current cell membrane-based drug delivery systems for effective subcellular targets and tumor therapy.

TL;DR: In this review, the recent studies about the effect of shape on delivery processes such as cellular uptake, tissue penetration and biodistribution are summarized and future perspectives on particle design are provided to improve the efficacy of drug delivery.

TL;DR: The strategy of combining the modulation of tumor vascular promotion with smart nanodrug delivery represents a promising approach to improving drug delivery and therapeutic efficacy in a wide range of hypoperfused tumors.

TL;DR: In vivo results proved the superior tumor permeability and improved oral bioavailability provided by the GMNP (21.9-fold over administration of crystalline drugs) and offer useful guidelines for the rational design of NPs by manipulating surface polymer conformation to realize multiple functions and to enhance delivery efficacy.