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Diana E. Bedolla

Researcher at Elettra Sincrotrone Trieste

Publications -  43
Citations -  556

Diana E. Bedolla is an academic researcher from Elettra Sincrotrone Trieste. The author has contributed to research in topics: Chemistry & Microscopy. The author has an hindex of 12, co-authored 33 publications receiving 357 citations. Previous affiliations of Diana E. Bedolla include AREA Science Park & Monash University.

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Soft X-Ray Microscopy Radiation Damage On Fixed Cells Investigated With Synchrotron Radiation FTIR Microscopy

TL;DR: Assessment of the impact of soft X-rays on formalin fixed cells on a systematic manner reveals that while cell morphology is not substantially affected, cellular biochemical profile changes significantly and progressively when increasing dose, resulting in a severe breakdown of the covalent bonding network.
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Contribution of Ribonucleic Acid (RNA) to the Fourier Transform Infrared (FTIR) Spectrum of Eukaryotic Cells

TL;DR: It is proved that the spectral contribution centered at ∼1120 cm-1 is the most reliable indicator of variations in cellular RNA levels, that better correlates with cellular metabolic activity.
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In vitro FTIR microspectroscopy analysis of primary oral squamous carcinoma cells treated with cisplatin and 5-fluorouracil: a new spectroscopic approach for studying the drug-cell interaction.

TL;DR: In vitro FTIRM analysis of primary oral squamous carcinoma cells evidenced a time-dependent drug-specific cellular response, also including apoptosis triggering, and the univariate and multivariate analyses of IR data evidenced meaningful spectroscopic differences ascribable to alterations affecting cellular proteins, lipids and nucleic acids.