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Igor Dolgalev
Researcher at New York University
Publications - 93
Citations - 12660
Igor Dolgalev is an academic researcher from New York University. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 31, co-authored 73 publications receiving 10106 citations. Previous affiliations of Igor Dolgalev include Cornell University & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Integrative genomic profiling of human prostate cancer
Barry S. Taylor,Nikolaus Schultz,Haley Hieronymus,Anuradha Gopalan,Yonghong Xiao,Brett S. Carver,Vivek K. Arora,Poorvi Kaushik,Ethan Cerami,Boris Reva,Yevgeniy Antipin,Nicholas Mitsiades,Thomas Landers,Igor Dolgalev,John E. Major,Manda Wilson,Nicholas D. Socci,Alex E. Lash,Adriana Heguy,James A. Eastham,Howard I. Scher,Victor E. Reuter,Peter T. Scardino,Chris Sander,Charles L. Sawyers,Charles L. Sawyers,William L. Gerald +26 more
TL;DR: Analysis of genomic and clinical outcome data from 218 prostate cancer tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score.
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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
Jay P. Patel,Mithat Gonen,Maria E. Figueroa,Hugo Fernandez,Zhuoxin Sun,Janis Racevskis,Pieter Van Vlierberghe,Igor Dolgalev,Sabrena Thomas,Olga Aminova,Kety Huberman,Janice Cheng,Agnes Viale,Nicholas D. Socci,Adriana Heguy,Athena M. Cherry,Gail H. Vance,Rodney R. Higgins,Rhett P. Ketterling,Robert E. Gallagher,Mark R. Litzow,Marcel R.M. van den Brink,Hillard M. Lazarus,Jacob M. Rowe,Selina M. Luger,Adolfo A. Ferrando,Elisabeth Paietta,Martin S. Tallman,Ari Melnick,Omar Abdel-Wahab,Ross L. Levine +30 more
TL;DR: Genetic predictors of outcome that improved risk stratification among patients with AML, independently of age, white-cell count, induction dose, and post-remission therapy, are identified and the significance of these predictors in an independent cohort is validated.
Journal ArticleDOI
Mutations in GNA11 in Uveal Melanoma
Catherine D. Van Raamsdonk,Klaus G. Griewank,Michelle B. Crosby,Maria C. Garrido,Swapna S. Vemula,Thomas Wiesner,Anna C. Obenauf,Werner Wackernagel,Gary G. R. Green,Nancy Bouvier,M. Mert Sozen,Gail Baimukanova,Ritu Roy,Adriana Heguy,Igor Dolgalev,Raya Khanin,Klaus J. Busam,Michael R. Speicher,Joan M. O'Brien,Boris C. Bastian +19 more
TL;DR: Constitutive activation of the pathway involving these two genes appears to be a major contributor to the development of uveal melanoma.
Journal ArticleDOI
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
Omar Abdel-Wahab,Ann Mullally,Cyrus V. Hedvat,Guillermo Garcia-Manero,Jay P. Patel,Martha Wadleigh,Sébastien Malinge,Jin Juan Yao,Outi Kilpivaara,Rukhmi Bhat,Kety Huberman,Sabrena Thomas,Igor Dolgalev,Adriana Heguy,Elisabeth Paietta,Michelle M. Le Beau,Miloslav Beran,Martin S. Tallman,Benjamin L. Ebert,Benjamin L. Ebert,Hagop M. Kantarjian,Richard Stone,D. Gary Gilliland,D. Gary Gilliland,D. Gary Gilliland,John D. Crispino,Ross L. Levine +26 more
TL;DR: In this paper, the mutational status of TET1, TET2, and TET3 in myeloproliferative neoplasms (MPNs), chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML) was evaluated.
Journal ArticleDOI
The bone marrow microenvironment at single-cell resolution.
Anastasia N. Tikhonova,Igor Dolgalev,Hai Hu,Kishor K. Sivaraj,Edlira Hoxha,Álvaro Cuesta-Domínguez,Sandra Pinho,Ilseyar Akhmetzyanova,Jie Gao,Matthew T. Witkowski,Maria Guillamot,Michael C. Gutkin,Yutong Zhang,Christian Marier,Catherine Diefenbach,Stavroula Kousteni,Adriana Heguy,Hua Zhong,David R. Fooksman,Jason M. Butler,Aris N. Economides,Paul S. Frenette,Ralf H. Adams,Rahul Satija,Aristotelis Tsirigos,Iannis Aifantis +25 more
TL;DR: This analysis revealed previously unappreciated levels of cellular heterogeneity within the bone marrow niche and resolved cellular sources of pro-haematopoietic growth factors, chemokines and membrane-bound ligands as well as substantial transcriptional remodelling under stress conditions.