Dionissios Papaioannou

TL;DR: The structure and the biological significance of naturally occurring and synthetic polyamine analogues and conjugates are presented and the available methodologies for their synthesis are described.

TL;DR: Previous and current efforts to synthesize CAM derivatives with improved pharmacological properties are presented and potentially broader roles of these derivatives in investigating the plasticity of the ribosomal catalytic center, the main target of CAM are highlighted.

TL;DR: The most potent compounds KukA and its analog 3, in which the DHCA units had been replaced by O,O9-dimethylcaffeic acid units, were studied for their anti-inflammatory activity in vivo on rat paw edema induced by carrageenan and found to be of comparable activity to indomethacin.

TL;DR: The designed conjugates proved to be suitable tools in investigating the ribosomal catalytic center plasticity and some of them exhibited greater efficacy than CAM itself.

TL;DR: Linear N(omegas)-tritylated omega-amino thiobenzylamides and N(alpha),N(omega)-ditritylated polyamino mono- or bisthioamides were efficiently converted to the corresponding tetrazole derivatives upon treatment with azidotrimethylsilane under Mitsunobu reaction conditions.