Journal ArticleDOI
Structure, Biological Activity and Synthesis of Polyamine Analogues and Conjugates
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TLDR
The structure and the biological significance of naturally occurring and synthetic polyamine analogues and conjugates are presented and the available methodologies for their synthesis are described.About:
This article is published in European Journal of Organic Chemistry.The article was published on 2000-05-01. It has received 104 citations till now. The article focuses on the topics: Solid-phase synthesis & Acylation.read more
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Sequence control in polymer synthesis
Nezha Badi,Jean-François Lutz +1 more
TL;DR: Both biological and synthetic mechanisms for controlling sequences in polymerization processes are critically discussed herein and may serve as a source of inspiration for the development of new generations of synthetic macromolecules.
Journal ArticleDOI
Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives.
TL;DR: A comprehensive review of the medicinal chemistry aspects in the development of various classes of nitrogen mustards (mechlorethamine, chlorambucil, melphalan, cyclophosphamide and steroidal based nitrogenmustards) including the historical and the latest developments in these areas are discussed.
Journal ArticleDOI
Chemoselective reductive alkylation of ammonia with carbonyl compounds: synthesis of primary and symmetrical secondary amines
TL;DR: In this article, an efficient, general procedure for highly chemoselective reductive mono-alkylation of ammonia with ketones is reported, followed by in situ sodium borohydride reduction, and a straightforward workup afforded primary amines in good yield.
Journal ArticleDOI
Direct Synthesis of Polyamides via Catalytic Dehydrogenation of Diols and Diamines
Hanxiang Zeng,Zhibin Guan +1 more
TL;DR: Compared with conventional condensation method, this catalytic system avoids the requirement of stoichiometric preactivation or in situ activation reagents and provides a much cleaner process with high atomic economy.
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Phthalocyanine-polyamine conjugates as highly efficient photosensitizers for photodynamic therapy.
TL;DR: Flow cytometric studies of two selected compounds against HT29 cells have shown that they induce apoptosis extensively, and these two compounds also show high affinity toward the lysosomes, but not the mitochondria, of the cells.
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Journal Article
Polyamine Metabolism and Its Importance in Neoplastic Growth and as a Target for Chemotherapy
TL;DR: It should soon prove possible to block polyamine biosynthesis at every step in the pathway, and this approach will enable a full examination of the potential of this approach.
Journal ArticleDOI
Polyamine metabolism and function.
Anthony E. Pegg,P. P. McCann +1 more
TL;DR: The reactions responsible for the biosynthesis and interconversion of the polyamines and their precursor putrescine are described and the means by which polyamine content can be varied in response to exogenous stimuli are discussed.
Journal ArticleDOI
1,4-Diaminobutane (Putrescine), Spermidine, and Spermine
C W Tabor,H Tabor +1 more
TL;DR: No specific mechanism has been firmly established for the action of the polyamines in vivo, however, it is clear that these compounds are physiologically important, and further work is necessary to establish the mechanism of their action.