D
Dirk Neumann
Researcher at Saarland University
Publications - 49
Citations - 1543
Dirk Neumann is an academic researcher from Saarland University. The author has contributed to research in topics: Epitope & Drug carrier. The author has an hindex of 22, co-authored 49 publications receiving 1378 citations. Previous affiliations of Dirk Neumann include University of Bonn.
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A new Lamarckian genetic algorithm for flexible ligand‐receptor docking
TL;DR: A Lamarckian genetic algorithm (LGA) variant for flexible ligand‐receptor docking which allows to handle a large number of degrees of freedom and may be used to dock ligands with many rotatable bonds with high efficiency.
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Lipid nanocapsules for dermal application: A comparative study of lipid-based versus polymer-based nanocarriers
TL;DR: The results would suggest that the LNC can be considered as efficient as SLN and NLC for the transdermal drug delivery while polymeric nanoparticles are more suitable for localized drug delivery to the skin.
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5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease.
David Pertuit,Brice Moulari,Thomas Betz,Arulraj Nadaradjane,Dirk Neumann,Lhassane Ismaili,Bernard Refouvelet,Yann Pellequer,Alf Lamprecht +8 more
TL;DR: These oral NP formulations demonstrated their therapeutic potential and appear to be an interesting approach for the therapy of inflammatory bowel disease.
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In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients.
Steffi Hansen,Andreas Henning,Arne Naegel,Michael Heisig,Gabriel Wittum,Dirk Neumann,Karl-Heinz Kostka,Jarmila Zbytovská,Claus-Michael Lehr,Ulrich F. Schaefer +9 more
TL;DR: For a two-dimensional model membrane consisting of a biphasic stratum corneum (SC) and a homogeneous epidermal/dermal compartment (DSL) methods are presented to determine all relevant input parameters.
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Finite and infinite dosing: Difficulties in measurements, evaluations and predictions ☆
TL;DR: An overview on typical finite and infinite dose experiments performed in fundamental research and on the evaluation of the data is given, point out possible difficulties that may arise and give a short overview on attempts at predicting skin absorption in vitro and in vivo.