D
Dmytro Kovalskyy
Researcher at Taras Shevchenko National University of Kyiv
Publications - 11
Citations - 266
Dmytro Kovalskyy is an academic researcher from Taras Shevchenko National University of Kyiv. The author has contributed to research in topics: Transcription (biology) & Cyclin T1. The author has an hindex of 8, co-authored 11 publications receiving 218 citations. Previous affiliations of Dmytro Kovalskyy include National Academy of Sciences of Ukraine & Georgetown University.
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Journal ArticleDOI
Role of Protein Phosphatase 1 in Dephosphorylation of Ebola Virus VP30 Protein and Its Targeting for the Inhibition of Viral Transcription
Philipp A. Ilinykh,Bersabeh Tigabu,Andrey Ivanov,Tatiana Ammosova,Yuri Obukhov,Tania Garron,Namita Kumari,Dmytro Kovalskyy,Dmytro Kovalskyy,M. O. Platonov,M. O. Platonov,Vasiliy S. Naumchik,Vasiliy S. Naumchik,Alexander N. Freiberg,Sergei Nekhai,Alexander Bukreyev +15 more
TL;DR: It is shown that EBOV VP30 is phosphorylated not only at the N-terminal serine clusters identified previously but also at the threonine residues at positions 143 and 146, suggesting a novel mechanism of regulation of VP30 phosphorylation.
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Small Molecules Targeted to a Non-Catalytic ‘‘RVxF’’Binding Site of Protein Phosphatase-1 Inhibit HIV-1
Tatiana Ammosova,M. O. Platonov,M. O. Platonov,Venkat R. K. Yedavalli,Yuri Obukhov,Victor R. Gordeuk,Victor R. Gordeuk,Kuan-Teh Jeang,Dmytro Kovalskyy,Dmytro Kovalskyy,Sergei Nekhai +10 more
TL;DR: This study shows that HIV- inhibition can be achieved through using small molecules to target a non-catalytic site of PP1, and can serve as a starting point for the development of novel antiviral drugs that target the interface of HIV-1 viral proteins with their host partners.
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Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription.
Rachel Van Duyne,Irene Guendel,Elizabeth Jaworski,Gavin C. Sampey,Zachary Klase,Hao Chen,Chen Zeng,Chen Zeng,Dmytro Kovalskyy,Mahmoud H. el Kouni,Benjamin Lepene,Alexis Patanarut,Sergei Nekhai,David H. Price,Fatah Kashanchi +14 more
TL;DR: The results suggest that it may be possible to model peptide inhibitors into available crystal structures and further find drug mimetics using in silico analysis, and found the new targets of Cavity 1 and Cavity 2 regions on CDK9.
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Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction.
Andriy Z. Buta,Oleksandr Maximyuk,Dmytro Kovalskyy,Volodymyr A. Sukach,Mykhailo V. Vovk,Oleksandr Ievglevskyi,Elena Isaeva,Dmytro Isaev,Alina Savotchenko,Oleg Krishtal +9 more
TL;DR: Novel 2-oxo-2H-chromene-3-carboxamidine derivative 5b, designed with molecular modeling approach, inhibits ASIC1a currents with an apparent IC50 of 27 nM when measured at pH 6.7, and suggests that compound 5b binds to pH sensor of ASIC 1a acting as orthosteric noncompetitive antagonist.
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1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.
Tatyana Ammosova,M. O. Platonov,M. O. Platonov,Andrei Ivanov,Yasemin Saygideger Kont,Namita Kumari,Kylene Kehn-Hall,Marina Jerebtsova,Amol A. Kulkarni,Aykut Üren,Dmytro Kovalskyy,Dmytro Kovalskyy,Sergei Nekhai +12 more
TL;DR: A low MW compound 1H4 is synthesized, that targets PP1 and prevents HIV‐1 Tat interaction withPP1 and inhibits HIV‐ 1 gene transcription.