D
Dmytro Ostrovskyi
Researcher at University of Freiburg
Publications - 24
Citations - 367
Dmytro Ostrovskyi is an academic researcher from University of Freiburg. The author has contributed to research in topics: Catalysis & Trifluoromethyl. The author has an hindex of 13, co-authored 24 publications receiving 330 citations. Previous affiliations of Dmytro Ostrovskyi include Taras Shevchenko National University of Kyiv & University of Rostock.
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Journal ArticleDOI
4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
Martin Hügle,Xavier Lucas,Gerhard Weitzel,Dmytro Ostrovskyi,Bernhard Breit,Stefan Gerhardt,Oliver Einsle,Stefan Günther,Daniel Wohlwend +8 more
TL;DR: A novel potent inhibitor of BET proteins, 1 (XD14) is developed, which exerts a strong inhibitory potential on the proliferation of specific leukemia cell lines and may substantially contribute to the development of therapeutics with increased target specificity against BRD4-related malignancies.
Journal ArticleDOI
Synthesis of fluorinated purine and 1-deazapurine glycosides as potential inhibitors of adenosine deaminase.
Viktor O. Iaroshenko,Viktor O. Iaroshenko,Dmytro Ostrovskyi,Dmytro Ostrovskyi,Andranik Petrosyan,Satenik Mkrtchyan,Alexander Villinger,Peter Langer +7 more
TL;DR: The synthesis of 2- and 6-trifluoromethylated purines and 1-deazapurines was performed by formal [3 + 3]-cyclization reactions of 5-aminoimidazoles and can be considered as potential inhibitors of adenosine deaminase (ADA).
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3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis
Satenik Mkrtchyan,Viktor O. Iaroshenko,Viktor O. Iaroshenko,Sergii Dudkin,Ashot Gevorgyan,Marcelo Vilches-Herrera,Gagik Ghazaryan,Dmitriy M. Volochnyuk,Dmitriy M. Volochnyuk,Dmytro Ostrovskyi,Zeeshan Ahmed,Alexander Villinger,Vyacheslav Ya. Sosnovskikh,Peter Langer +13 more
TL;DR: The first synthesis of 3-methoxalylchromone was described, where the reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO(2)Me substituent located at the α-position of the pyridine core.
Journal ArticleDOI
A general strategy for the synthesis of difluoromethyl-containing pyrazoles, pyridines and pyrimidines
Viktor O. Iaroshenko,Viktor O. Iaroshenko,Verena Specowius,Katharina Vlach,Marcelo Vilches-Herrera,Dmytro Ostrovskyi,Satenik Mkrtchyan,Alexander Villinger,Peter Langer +8 more
TL;DR: In this paper, the CF 2 Cl-substituted 1,3-dicarbonyl compounds were used to obtain difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles.
Journal ArticleDOI
Design and Synthesis of Polycyclic Imidazole-Containing N- Heterocycles based on CH Activation/Cyclization Reactions
Viktor O. Iaroshenko,Viktor O. Iaroshenko,Dmytro Ostrovskyi,Mariia Miliutina,Aneela Maalik,Alexander Villinger,Andrei A. Tolmachev,Andrei A. Tolmachev,Dmitriy M. Volochnyuk,Dmitriy M. Volochnyuk,Peter Langer +10 more
TL;DR: In this paper, a new strategy for the synthesis of poly-cyclic imidazole-containing N-heterocycles, based on the two general synthetic ways, namely the Pd(II)- catalyzed intramolecular arylation via CH/CHal and CH/ CH coupling reactions, was developed.