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Dominique H. Limoli
Researcher at University of Iowa
Publications - 25
Citations - 1722
Dominique H. Limoli is an academic researcher from University of Iowa. The author has contributed to research in topics: Pseudomonas aeruginosa & Staphylococcus aureus. The author has an hindex of 13, co-authored 20 publications receiving 1195 citations. Previous affiliations of Dominique H. Limoli include Emory University & The Research Institute at Nationwide Children's Hospital.
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Journal ArticleDOI
Bacterial Extracellular Polysaccharides in Biofilm Formation and Function.
TL;DR: The diverse range of polysaccharide structures, properties, and roles highlight the importance of this matrix constituent to the successful adaptation of bacteria to nearly every niche.
Journal ArticleDOI
Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection
Anwari Akhter,Mikhail A. Gavrilin,Laura J. Frantz,Songcerae Washington,Cameron Ditty,Dominique H. Limoli,Colby Day,Anasuya Sarkar,Christie A. Newland,Jonathan P. Butchar,Clay B. Marsh,Mark D. Wewers,Susheela Tridandapani,Thirumala-Devi Kanneganti,Amal O. Amer +14 more
TL;DR: Using the intracellular pathogen L. pneumophila, it is shown that, upon infection of murine macrophages, caspase-7 was activated downstream of the Nlrc4 inflammasome and required casp enzyme-1 activation, and a novel biological role for caspasing-7 in host defense against an intrACEllular bacterium is presented.
Journal ArticleDOI
ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.
Christopher J. Jones,Christopher J. Jones,David E. Newsom,Benjamin J. Kelly,Yasuhiko Irie,Laura K. Jennings,Binjie Xu,Dominique H. Limoli,Joe J. Harrison,Matthew R. Parsek,Peter T White,Daniel J. Wozniak,Daniel J. Wozniak +12 more
TL;DR: The comprehensive regulon of a bifunctional transcriptional regulator is defined and a c-di-GMP mediated mechanism for AmrZ regulation of biofilm formation and chronicity is identified.
Journal ArticleDOI
Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection.
Dominique H. Limoli,Dominique H. Limoli,Gregory B. Whitfield,Tomoe Kitao,Tomoe Kitao,Melissa L. Ivey,Michael Davis,Nora Grahl,Deborah A. Hogan,Laurence G. Rahme,Laurence G. Rahme,P. Lynne Howell,George A. O'Toole,Joanna B. Goldberg,Joanna B. Goldberg +14 more
TL;DR: Production of alginate in mucoid strains is sufficient to inhibit anti-S.
Journal ArticleDOI
Staphylococcus aureus and Pseudomonas aeruginosa co-infection is associated with cystic fibrosis-related diabetes and poor clinical outcomes
Dominique H. Limoli,J. Yang,M. K. Khansaheb,B. Helfman,L. Peng,A. A. Stecenko,Joanna B. Goldberg +6 more
TL;DR: CFRD patients, particularly those with extremely high blood glucose levels, were more likely than NGT patients to be co-infected with S. aureus and P. aeruginosa, compared to infection with only one pathogen, which may account for greater pulmonary decline in CFRD patients.