D
Dominique Melck
Researcher at National Research Council
Publications - 69
Citations - 6242
Dominique Melck is an academic researcher from National Research Council. The author has contributed to research in topics: Anandamide & Cannabinoid receptor. The author has an hindex of 36, co-authored 68 publications receiving 5931 citations. Previous affiliations of Dominique Melck include University of Naples Federico II & ARCO.
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Journal ArticleDOI
Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin.
TL;DR: Data indicate that DAG precursors for 2‐AG in intact N18TG2 cells are obtained from the hydrolysis of PA and not through the activation of PLC, which would indicate that the PA‐dependent pathways of 2‐ AG formation are avoided.
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NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis
Paolo Montuschi,Debora Paris,Dominique Melck,Vincenzina Lucidi,Giovanni Ciabattoni,Valeria Raia,Cecilia Calabrese,Andrew Bush,Peter J. Barnes,Andrea Motta +9 more
TL;DR: Nuclear magnetic resonance spectroscopy of exhaled breath condensate is reproducible, discriminates patients with CF from healthy subjects and patients with unstable CF from those with stable CF, and identifies the metabolites responsible for between-group differences.
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Cannabimimetic Fatty Acid Derivatives: The Anandamide Family and Other “Endocannabinoids”
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Metabonomic analysis of exhaled breath condensate in adults by nuclear magnetic resonance spectroscopy
G. de Laurentiis,Debora Paris,Dominique Melck,Mauro Maniscalco,Serafino A. Marsico,Gaetano Corso,Andrea Motta,Matteo Sofia +7 more
TL;DR: The nuclear magnetic resonance metabonomic approach could identify the metabolic fingerprint of exhaled breath condensate in different clinical sets of data and can discriminate potential perturbations induced by pre-analytical variables.
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Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase.
L. De Petrocellis,Dominique Melck,Natsuo Ueda,S. Maurelli,Yuko Kurahashi,Shozo Yamamoto,Gennaro Marino,V. Di Marzo +7 more
TL;DR: Three arachidonic acid analogues synthesized by adding to the fatty acid moiety three functional groups previously used to synthesize irreversible inhibitors of serine and cysteine proteases produced an apparent increase of the in vitro formation of anandamide from its biosynthetic precursor N-arachidonoyl-phosphatidyl-ethanolamine.