D
Dominique Melck
Researcher at National Research Council
Publications - 69
Citations - 6242
Dominique Melck is an academic researcher from National Research Council. The author has contributed to research in topics: Anandamide & Cannabinoid receptor. The author has an hindex of 36, co-authored 68 publications receiving 5931 citations. Previous affiliations of Dominique Melck include University of Naples Federico II & ARCO.
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Journal ArticleDOI
Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells
Tiziana Bisogno,Kazuhisa Katayama,Dominique Melck,Natsuo Ueda,Luciano De Petrocellis,Shozo Yamamoto,Vincenzo Di Marzo +6 more
TL;DR: The data show for the first time that induction by nerve growth factor of a sympathetic neuronal phenotype in PC-12 cells has no effect on arachidonoylethanolamide/oleamide metabolism, and arachtidonoyleanolamide and oleamide are autacoid suppressors of human breast cancer cell proliferation.
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Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate.
Guglielmo de Laurentiis,Debora Paris,Dominique Melck,Paolo Montuschi,Mauro Maniscalco,Andrea Bianco,Matteo Sofia,Andrea Motta +7 more
TL;DR: The specificity of EBC profiles suggests that disease itself drives metabolic separation overwhelming the "common background" due to smoking habit, and offers a powerful tool for assessing the evolution of airway diseases even in the presence of a strong common factor.
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Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine
Vladimir V. Bezuglov,Mikhail Bobrov,Natalia Gretskaya,Alla Gonchar,G. N. Zinchenko,Dominique Melck,Tiziana Bisogno,Vincenzo Di Marzo,Kuklev Dv,Jean-Claude Rossi,Jean-Pierre Vidal,Thierry Durand +11 more
TL;DR: It is demonstrated that polyenoic fatty acid amides with dopamine comprise a new family of synthetic cannabimimetics.
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Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide.
Vincenzo Di Marzo,Christopher S. Breivogel,Tiziana Bisogno,Dominique Melck,Gray Patrick,Qing Tao,Arpad Szallasi,Raj K. Razdan,Billy R. Martin +8 more
TL;DR: The data indicate that the neurobehavioral effects exerted by arvanil are not due to activation of cannabinoid CB(1) or vanilloid VR(1), and the cannabimimetic properties of N-vanillyl-arachidonoyl-amide were studied.
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Cannabimimetic fatty acid derivatives in cancer and inflammation.
TL;DR: In human breast and prostate cancer cells, AEA and 2-AG, but not PEA, potently inhibit prolactin and/or nerve growth factor (NGF)-induced cell proliferation, and the possibility that CFADs act as local inhibitors of the proliferation of human breast cancer is discussed here.