D
Dominique Stoppa-Lyonnet
Researcher at Curie Institute
Publications - 444
Citations - 32995
Dominique Stoppa-Lyonnet is an academic researcher from Curie Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 80, co-authored 420 publications receiving 29316 citations. Previous affiliations of Dominique Stoppa-Lyonnet include PSL Research University & Bosch.
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Journal ArticleDOI
Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations.
Isabelle Coupier,Céline Baldeyron,Alexandra Rousseau,Véronique Mosseri,Sabine Pagès-Berhouet,Virginie Caux-Moncoutier,Dora Papadopoulo,Dominique Stoppa-Lyonnet +7 more
TL;DR: The fidelity of DSB repair in four lymphoblastoid cell lines with BRCA1 missense mutations was impaired and the fidelity of end-joining was similar to that of a truncated mutation control cell line for one cell line and slightly higher for the other cell lines.
Journal ArticleDOI
Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers.
Lisa Golmard,Laurent Castera,Sophie Krieger,Sophie Krieger,Virginie Moncoutier,Khadija Abidallah,Henrique Tenreiro,Anthony Laugé,Julien Tarabeux,Gaël A. Millot,Gaël A. Millot,André Nicolas,Marick Laé,Caroline Abadie,Pascaline Berthet,Florence Polycarpe,Thierry Frebourg,Thierry Frebourg,Camille Elan,Antoine De Pauw,Marion Gauthier-Villars,Bruno Buecher,Marc-Henri Stern,Marc-Henri Stern,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,Dominique Vaur,Claude Houdayer,Claude Houdayer +28 more
TL;DR: This study is the first evaluation of the five RAD51 paralogs in breast and ovarian cancer predisposition and it demonstrates that deleterious variants can be present in breast cancer only cases.
Journal ArticleDOI
Impact of BRCA1 and BRCA2 variants on splicing: clues from an allelic imbalance study
Virginie Caux-Moncoutier,Sabine Pagès-Berhouet,Dorothée Michaux,Bernard Asselain,Laurent Castera,Antoine De Pauw,Bruno Buecher,Marion Gauthier-Villars,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,Claude Houdayer,Claude Houdayer +11 more
TL;DR: Overall, this study showed that AI screening is a simple way to detect deleterious splicing defects and that a major role for VUSs and deep intronic mutations in splicing anomalies is unlikely in BRCA1/2 genes.
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Breast and ovarian cancer predisposition due to de novo BRCA1 and BRCA2 mutations
Lisa Golmard,Capucine Delnatte,Anthony Laugé,Virginie Moncoutier,Cédrick Lefol,Khadija Abidallah,Henrique Tenreiro,F Copigny,M Giraudeau,Christophe Guy,Catherine Barbaroux,G Amorim,Adrien Briaux,V Guibert,Julien Tarabeux,Sandrine M. Caputo,Agnès Collet,Paul Gesta,O Ingster,M-H Stern,Etienne Rouleau,A. De Pauw,Marion Gauthier-Villars,Bruno Buecher,Stéphane Bézieau,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,Claude Houdayer,Claude Houdayer +28 more
TL;DR: Although rare, it may be useful to take the possibility of de novo BRCA1/2 mutation into account in genetic counseling of relatives and to improve the understanding of complex family histories of breast and ovarian cancers.
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BRCA1/2 carriers: their childbearing plans and theoretical intentions about having preimplantation genetic diagnosis and prenatal diagnosis
Claire Julian-Reynier,Roxane Fabre,Roxane Fabre,Isabelle Coupier,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,Christine Lasset,Olivier Caron,Emmanuelle Mouret-Fourme,Pascaline Berthet,Laurence Faivre,Marc Frenay,Paul Gesta,Laurence Gladieff,Anne-Déborah Bouhnik,Anne-Déborah Bouhnik,Christel Protière,Christel Protière,Catherine Noguès +18 more
TL;DR: The closer to reproductive decision-making BRCA1/2 carriers are, i.e., when they are more likely to be making future reproductive plans, the less frequently they intend to have PGD.