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Dominique Stoppa-Lyonnet
Researcher at Curie Institute
Publications - 444
Citations - 32995
Dominique Stoppa-Lyonnet is an academic researcher from Curie Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 80, co-authored 420 publications receiving 29316 citations. Previous affiliations of Dominique Stoppa-Lyonnet include PSL Research University & Bosch.
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GENESIS: a French national resource to study the missing heritability of breast cancer
Olga M. Sinilnikova,Marie-Gabrielle Dondon,Séverine Eon-Marchais,Francesca Damiola,Laure Barjhoux,Morgane Marcou,Carole Verny-Pierre,Valérie Sornin,Lucie Toulemonde,Juana Beauvallet,Dorothée Le Gal,Noura Mebirouk,Muriel Belotti,Olivier Caron,Marion Gauthier-Villars,Isabelle Coupier,Bruno Buecher,Alain Lortholary,Catherine Dugast,Paul Gesta,Jean-Pierre Fricker,Catherine Noguès,Laurence Faivre,Elisabeth Luporsi,Pascaline Berthet,Capucine Delnatte,Valérie Bonadona,Valérie Bonadona,Christine Maugard,Pascal Pujol,Christine Lasset,Christine Lasset,Michel Longy,Yves-Jean Bignon,Claude Adenis,Laurence Venat-Bouvet,Liliane Demange,Hélène Dreyfus,Marc Frenay,Laurence Gladieff,Isabelle Mortemousque,Séverine Audebert-Bellanger,Florent Soubrier,Sophie Giraud,Sophie Lejeune-Dumoulin,Annie Chevrier,Jean-Marc Limacher,Jean Chiesa,Anne Fajac,Anne Floquet,François Eisinger,Julie Tinat,Chrystelle Colas,Sandra Fert-Ferrer,Clotilde Penet,Thierry Frebourg,Marie-Agnès Collonge-Rame,Emmanuelle Barouk-Simonet,Valérie Layet,Dominique Leroux,Odile Cohen-Haguenauer,Fabienne Prieur,Emmanuelle Mouret-Fourme,François Cornelis,Philippe Jonveaux,Odile Bera,Eve Cavaciuti,Anne Tardivon,Fabienne Lesueur,Sylvie Mazoyer,Dominique Stoppa-Lyonnet,Nadine Andrieu +71 more
TL;DR: The size of the study, the availability of biological specimens and the clinical data collection together with the detailed and complete epidemiological questionnaire make this a unique national resource for investigation of the missing heritability of breast cancer, by taking into account environmental and life style factors and stratifying data on endophenotypes to decrease genetic heterogeneity.
Journal ArticleDOI
GEMO, a National Resource to Study Genetic Modifiers of Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Pathogenic Variant Carriers
Fabienne Lesueur,Noura Mebirouk,Yue Jiao,Laure Barjhoux,Muriel Belotti,Maite Laurent,Mélanie Léoné,Claude Houdayer,Brigitte Bressac-de Paillerets,Dominique Vaur,Hagay Sobol,Catherine Noguès,Michel Longy,Isabelle Mortemousque,Sandra Fert-Ferrer,Emmanuelle Mouret-Fourme,Pascal Pujol,Laurence Venat-Bouvet,Yves-Jean Bignon,Dominique Leroux,Isabelle Coupier,Pascaline Berthet,Véronique Mari,Capucine Delnatte,Paul Gesta,Marie-Agnès Collonge-Rame,Sophie Giraud,Valérie Bonadona,Valérie Bonadona,Amandine Baurand,Laurence Faivre,Bruno Buecher,Christine Lasset,Christine Lasset,Marion Gauthier-Villars,Francesca Damiola,Sylvie Mazoyer,Sandrine M. Caputo,Nadine Andrieu,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet +40 more
TL;DR: Both retrospective and prospective studies are still very much needed to refine individual cancer risk estimates by considering other genetic and lifestyle/environmental factors, and they will also contribute to a better understanding of the correlation between mutant BRCA1/2 alleles and phenotype.
Journal ArticleDOI
Fertility defects revealing germline biallelic nonsense NBN mutations.
Mathilde Warcoin,James Lespinasse,Gilles Despouy,Gilles Despouy,Catherine Dubois d'Enghien,Anthony Laugé,Marie-France Portnoï,Marie-France Portnoï,Sophie Christin-Maitre,Dominique Stoppa-Lyonnet,Marc-Henri Stern +10 more
TL;DR: Biological analyses revealed defects similar to those observed in NBS patients, including chromosomal instability, cellular hyperradiosensitivity and checkpoint defects as measured by radioresistant DNA synthesis (RDS).
Expertise collective inserm-fnclcc recommandations portant sur la prise en charge des femmes ayant un risque d'origine génétique de développer un cancer du sein et/ou de l'ovaire
François Eisinger,Nicole Alby,Alain Bremond,Jacques Dauplat,Marc Espié,Paul Janiaud,Frédérique Kuttenn,Jean-Pierre Lebrun,J.-P. Lefranc,Janine Pierret,Hagay Sobol,Dominique Stoppa-Lyonnet,Dominique Thouvenin,Henri Tristant,Josué Feingold +14 more
TL;DR: In this paper, les genes les plus souvent retrouves sont BRCA1 and BRCa2, and les interventions analysees ont ete les suivantes : interventions hormonales, prevention primaire, depistage (clinique et par imagerie) and enfin le probleme de la chirurgie prophylactique.
Journal Article
Are the hereditary forms of BRCA1 and BRCA2 breast cancer sensitive to estrogens
TL;DR: Prospective studies are required to estimate the potential benefits of estrogen suppression therapies for prevention or adjuvant treatment of familial breast cancer.