D
Donald A. Mahler
Researcher at Dartmouth College
Publications - 124
Citations - 9289
Donald A. Mahler is an academic researcher from Dartmouth College. The author has contributed to research in topics: COPD & Indacaterol. The author has an hindex of 44, co-authored 114 publications receiving 8526 citations. Previous affiliations of Donald A. Mahler include Yale University & Valley Regional Hospital.
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Journal ArticleDOI
Neuromodulatory Effect of Endogenous Opioids on the Intensity and Unpleasantness of Breathlessness during Resistive Load Breathing in COPD
Alex H. Gifford,Donald A. Mahler,Laurie A. Waterman,Joseph Ward,William J. Kraemer,Brian R. Kupchak,John C. Baird +6 more
TL;DR: Endogenous opioids modulate the intensity and the unpleasantness of breathlessness in patients with COPD and differences in breathlessness ratings between interventions were clinically relevant based on the patients’ global assessment.
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Management of dyspnea in patients with advanced lung or heart disease: practical guidance from the American college of chest physicians consensus statement.
TL;DR: There was consensus that patients with advanced lung or heart disease should be asked about the intensity and distress of their breathlessness; pursed-lips breathing, relaxation, oxygen for those with hypoxemia, noninvasive positive pressure ventilation, and oral/parental opioids can provide relief of dyspnea.
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Measurement of dyspnea and quality of life in advanced lung disease
Donald A. Mahler,Paul W. Jones +1 more
TL;DR: The authors anticipate a growing interest in measurement of clinical outcomes for patients with advanced lung diseases in the foreseeable future and expect that current instruments may be modified and that new tools will be developed in an attempt to improve the ability to measure dyspnea and HRQOL.
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Recent advances in COPD disease management with fixed-dose long-acting combination therapies.
Eric D. Bateman,Donald A. Mahler,Claus Vogelmeier,Jadwiga A. Wedzicha,Francesco Patalano,Donald Banerji +5 more
TL;DR: This review summarizes published efficacy and safety data from clinical trials of bothLABA/LAMA and novel LABA/ICS combinations in patients with COPD.
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Perceptual and Physiologic Responses During Treadmill and Cycle Exercise in Patients With COPD
TL;DR: Patients with COPD exhibit different perceptual and physiologic responses during treadmill walking and cycling, and ratings of breathlessness are initially higher with cycling at equivalent levels of Vo(2), while changes in breathlessness as a function of physiologic stimuli are greater during treadmill exercise.