D
Donald L. Price
Researcher at Johns Hopkins University
Publications - 471
Citations - 93184
Donald L. Price is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cholinergic neuron & Senile plaques. The author has an hindex of 128, co-authored 471 publications receiving 90448 citations. Previous affiliations of Donald L. Price include Johns Hopkins University School of Medicine & Dartmouth–Hitchcock Medical Center.
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Journal ArticleDOI
Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction.
Jocelyne Bachevalier,Linda S. Landis,Lary C. Walker,Mimi Brickson,Mortimer Mishkin,Donald L. Price,Linda C. Cork +6 more
TL;DR: The finding of correlations between scores of aged animals primarily within test categories as opposed to across categories suggests that different animals have different patterns of cerebral involvement.
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Cholinergic innervation in neuritic plaques.
TL;DR: Observed changes in cortical cholinergic innervation are an important feature in the pathogenesis and evolution of the neuritic plaque, and the number of neurites and the activity of acetylcholinesterase decreased.
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Botulinum Toxin: Mechanism of Presynaptic Blockade
TL;DR: The mechanism of action of botulinum toxin was analyzed by the use of calcium ionophores and black widow spider venom to suggest that the toxin interferes with the acetylcholine release process itself, possibly by blocking exocytosis at the release sites.
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Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington’s disease brain nuclei
Marcela Karpuj,Hideki Garren,Hilda H. Slunt,Donald L. Price,James F. Gusella,Mark W. Becher,Lawrence Steinman,Lawrence Steinman +7 more
TL;DR: TGase-mediated crosslinking of htt may be involved in the formation of the nonamyloidogenic nuclear inclusions found in the HD brain, and the staining properties of nuclear in Included revealed that they were not amyloid.
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Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys
TL;DR: In this article, the authors investigated age-related changes in the GABAergic, glutamatergic, and cholinergic neurotransmitter systems in rats and rhesus monkeys.