D
Donald L. Price
Researcher at Johns Hopkins University
Publications - 471
Citations - 93184
Donald L. Price is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cholinergic neuron & Senile plaques. The author has an hindex of 128, co-authored 471 publications receiving 90448 citations. Previous affiliations of Donald L. Price include Johns Hopkins University School of Medicine & Dartmouth–Hitchcock Medical Center.
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Abnormalities of the nucleus basalis in Down's syndrome.
TL;DR: The results show that the nbM contains fewer neurons in young persons with Down's syndrome than in normal controls and suggest that the number of these nerve cells may be further reduced in older persons with down's syndrome.
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Reductions in [3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study.
Peter J. Whitehouse,Andrea M. Martino,Molly V. Wagster,Donald L. Price,Richard Mayeux,John R. Atack,Kenneth J. Kellar +6 more
TL;DR: Receptor autoradiography is used to map the distribution of nicotinic [3H]acetylcholine binding sites in cortices of individuals with AD and PD and matched control subjects to study changes in cholinergic receptor binding sites.
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Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation
Jing Wu,Ronald S. Petralia,Hideaki Kurushima,Hiral Patel,Mi Young Jung,Lenora J Volk,Shoaib Chowdhury,Jason D. Shepherd,Marlin H. Dehoff,Yueming Li,Dietmar Kuhl,Richard L. Huganir,Donald L. Price,Robert H. Scannevin,Juan C. Troncoso,Philip C. Wong,Paul F. Worley +16 more
TL;DR: It is reported that the immediate early gene Arc is required for activity-dependent generation of Aβ, and it is hypothesized that Arc participates in the pathogenesis of AD.
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Human nerve growth factor improves spatial memory in aged but not in young rats
TL;DR: Data indicate that human NGF can reverse age-related cognitive impairments in old rats, but the present study also raises the issue of potential detrimental effects that NGF may exert in young normal subjects.
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Topography of the magnocellular basal forebrain system in human brain.
TL;DR: The present report describes the topographical distribution of these large, intensely basophilic, basal forebrain neurons in human brain and suggests that degeneration of these cells contributes to the loss of presynaptic cortical cholingergic markers which occurs in these patients.