D
Donald L. Price
Researcher at Johns Hopkins University
Publications - 471
Citations - 93184
Donald L. Price is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cholinergic neuron & Senile plaques. The author has an hindex of 128, co-authored 471 publications receiving 90448 citations. Previous affiliations of Donald L. Price include Johns Hopkins University School of Medicine & Dartmouth–Hitchcock Medical Center.
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Journal ArticleDOI
Evidence for cholinergic neurites in senile plaques
Cheryl A. Kitt,Donald L. Price,Robert G. Struble,Linda C. Cork,Bruce H. Wainer,Mark W. Becher,William C. Mobley,William C. Mobley +7 more
TL;DR: In the neocortices and amygdalae of young and aged macaques, cholinergic axons were identified by means of a monoclonal antibody to bovine choline acetyltransferase and many fine, linear, immunoreactive profiles were seen.
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Rapid anterograde axonal transport of the cellular prion glycoprotein in the peripheral and central nervous systems.
David R. Borchelt,Vassilis E. Koliatsos,Michael Guarnieri,Carlos A. Pardo,Sangram S. Sisodia,Donald L. Price +5 more
TL;DR: The trafficking of PrPc in neurons was investigated in vivo by injecting [35S]methionine into the L4 and L5 dorsal root ganglia and the entorhinal cortices of adult rats and by tracing the movement of radiolabeled PrPp, to determine whether it is converted into PrpSc during axonal transport and whether PrPSc is transported in animals with prion diseases.
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Slowing of the axonal transport of neurofilament proteins during development
TL;DR: It is proposed that the velocity of slow axonal transport reflects the level of maturation of the neuron, and that the presence of several overlapping peaks of transported radioactivity in the sciatic nerve of younger animals reflects the presenceof several populations of motor axons at different stages of development.
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High Molecular Weight Neurofilament Proteins Are Physiological Substrates of Adduction by the Lipid Peroxidation Product Hydroxynonenal
Takafumi Wataya,Akihiko Nunomura,Mark A. Smith,Sandra L. Siedlak,Peggy L.R. Harris,Shun Shimohama,Luke I. Szweda,Matthew A. Kaminski,Jesus Avilá,Donald L. Price,Don W. Cleveland,Lawrence M. Sayre,George Perry +12 more
TL;DR: These studies indicate that HNE adduction to NFH is physiological, and its constancy from birth to senility as well as its dependence on phosphorylation argues that NFH and NFM modification may play a role in protecting the membrane-rich axon from toxic aldehydes resulting from oxidative damage.
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Altered Metabolism of Familial Alzheimer's Disease-Linked Amyloid Precursor Protein Variants in Yeast Artificial Chromosome Transgenic Mice
Bruce T. Lamb,Linda M. Call,Hilda H. Slunt,Kimberly A. Bardel,Ann M. Lawler,Christopher B. Eckman,Steven G. Younkin,Greg Holtz,Steven L. Wagner,Donald L. Price,Sangram S. Sisodia,John D. Gearhart +11 more
TL;DR: High levels of A beta peptides are detected in the brains of YAC transgenic mice expressing human APP(K670N/M671L) that is associated with a concomitant diminution in the levels of apha-secretase-generated soluble APP derivatives.