D
Donald L. Price
Researcher at Johns Hopkins University
Publications - 471
Citations - 93184
Donald L. Price is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cholinergic neuron & Senile plaques. The author has an hindex of 128, co-authored 471 publications receiving 90448 citations. Previous affiliations of Donald L. Price include Johns Hopkins University School of Medicine & Dartmouth–Hitchcock Medical Center.
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Journal ArticleDOI
Potential use of nerve growth factor to treat Alzheimer's disease
Creighton H. Phelps,Fred H. Gage,John H. Growdon,Franz Hefti,Robert E. Harbaugh,M. V. Johnston,Zaven S. Khachaturian,William C. Mobley,Donald L. Price,Murray A. Raskind,James W. Simpkins,Leon J. Thal,J. Woodcock +12 more
Journal ArticleDOI
Senile plaques in cortex of aged normal monkeys.
TL;DR: As total plaque density increased, there was a linear increase in the density of amyloid plaques, suggesting that plaques evolve from neurite, to mixed, to amyloids types.
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Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.
Gabriele Schilling,Jonathan D. Wood,K. Duan,Hilda H. Slunt,Vicky Gonzales,Mitsunori Yamada,Jillian K. Cooper,Russell L. Margolis,Nancy A. Jenkins,Neal G. Copeland,Hitoshi Takahashi,Shoji Tsuji,Donald L. Price,David R. Borchelt,Christopher A. Ross +14 more
TL;DR: It is concluded that the evolution of neuropathology in DRPLA involves proteolytic processing of mutant atrophin-1 and nuclear accumulation of truncated fragments.
Journal Article
Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex.
TL;DR: It is concluded that morphological abnormalities at synapses precede the accumulation of the amyloid precursor protein within neurites and activated astrocytes and microglia as well as the deposition of extracellular fibrillar beta-amyloid protein.
Journal ArticleDOI
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
Ying Liu,Mi Jeong Yoo,Alena Savonenko,Wanda Stirling,Donald L. Price,David R. Borchelt,David R. Borchelt,Laura A. Mamounas,Laura A. Mamounas,W. Ernest Lyons,W. Ernest Lyons,Mary E. Blue,Michael K. Lee +12 more
TL;DR: The results show that a transgenic mouse model of Aβ pathology develops progressive MAergic neurodegeneration occurring in AD cases, and it is shown that the progression forebrain Aβ deposition in the APPswe/PS1ΔE9 model is associated with progressive losses of the forebrain MAergic afferents.