D
Donato Alarcón-Segovia
Researcher at National Autonomous University of Mexico
Publications - 269
Citations - 13130
Donato Alarcón-Segovia is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Lupus erythematosus & Antibody. The author has an hindex of 55, co-authored 269 publications receiving 12796 citations. Previous affiliations of Donato Alarcón-Segovia include Soroka Medical Center & Universidad Autónoma de San Luis Potosí.
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Journal ArticleDOI
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
Ludmila Prokunina,Casimiro Castillejo-López,Fredrik Öberg,Iva Gunnarsson,Louise Berg,Veronica Magnusson,Anthony J. Brookes,Dmitry Tentler,Helga Kristjansdottir,Gerdur Grondal,Anne Isine Bolstad,Anne Isine Bolstad,Elisabet Svenungsson,Ingrid E. Lundberg,Gunnar Sturfelt,Andreas Jönssen,Lennart Truedsson,Guadalupe Lima,Jorge Alcocer-Varela,Roland Jonsson,Ulf Gyllensten,John B. Harley,Donato Alarcón-Segovia,Kristjan Steinsson,Marta E. Alarcón-Riquelme +24 more
TL;DR: It is shown that one intronic SNP in PDCD1 is associated with development of SLE in Europeans, and this SNP alters a binding site for the runt-related transcription factor 1 (RUNX1) located in an intronic enhancer, suggesting a mechanism through which it can contribute to the development ofSLE in humans.
Journal ArticleDOI
Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients.
Donato Alarcón-Segovia,Delezé M,Oria Cv,Sánchez-Guerrero J,Gomez-Pacheco L,Cabiedes J,Fernández L,Ponce de León S +7 more
TL;DR: Doctors should be cautious in prescribing high doses of corticosteroids or immunosuppressants to patients with SLE solely because they have high titers of ACLA, and it is proposed that such criteria could be applied to the definition of the antiphospholipid syndrome.
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Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus.
Luis Llorente,Weiping Zou,Yves Levy,Yvonne Richaud-Patin,John Wijdenes,Jorge Alcocer-Varela,Brigitte Morel-Fourrier,Jean Claude Brouet,Donato Alarcón-Segovia,Pierre Galanaud,Dominique Emilie +10 more
TL;DR: The results indicate that the Ig production by SLE B lymphocytes is largely IL-10 dependent, and that the increased production ofIL-10 by Sle B lymphocyte and monocytes may represent a critical mechanism in the emergence of the autoimmune manifestations of the disease.
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Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus
Luis Llorente,Yvonne Richaud-Patin,Carlos García-Padilla,Emmanuel Claret,Juan Jakez-Ocampo,Mario H. Cardiel,Jorge Alcocer-Varela,Liliane Grangeot-Keros,Donato Alarcón-Segovia,John Wijdenes,Pierre Galanaud,Dominique Emilie +11 more
TL;DR: The study shows the involvement ofIL-10 in the pathogenesis of SLE, and indicates that the use of IL-10 antagonists may be beneficial in the management of refractory SLE.
Journal ArticleDOI
Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort.
Donato Alarcón-Segovia,Marta E. Alarcón-Riquelme,Mario H. Cardiel,Francisco Caeiro,Loreto Massardo,A R Villa,Bernardo A. Pons-Estel +6 more
TL;DR: American Indian-white Mestizo SLE patients and those with higher socioeconomic level were more likely to have familial autoimmunity and a polygenic additive model applies for SLE.