C
Casimiro Castillejo-López
Researcher at Uppsala University
Publications - 20
Citations - 1193
Casimiro Castillejo-López is an academic researcher from Uppsala University. The author has contributed to research in topics: Adipose tissue & Insulin resistance. The author has an hindex of 9, co-authored 16 publications receiving 1091 citations. Previous affiliations of Casimiro Castillejo-López include Oklahoma Medical Research Foundation & Lund University.
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Journal ArticleDOI
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
Ludmila Prokunina,Casimiro Castillejo-López,Fredrik Öberg,Iva Gunnarsson,Louise Berg,Veronica Magnusson,Anthony J. Brookes,Dmitry Tentler,Helga Kristjansdottir,Gerdur Grondal,Anne Isine Bolstad,Anne Isine Bolstad,Elisabet Svenungsson,Ingrid E. Lundberg,Gunnar Sturfelt,Andreas Jönssen,Lennart Truedsson,Guadalupe Lima,Jorge Alcocer-Varela,Roland Jonsson,Ulf Gyllensten,John B. Harley,Donato Alarcón-Segovia,Kristjan Steinsson,Marta E. Alarcón-Riquelme +24 more
TL;DR: It is shown that one intronic SNP in PDCD1 is associated with development of SLE in Europeans, and this SNP alters a binding site for the runt-related transcription factor 1 (RUNX1) located in an intronic enhancer, suggesting a mechanism through which it can contribute to the development ofSLE in humans.
Journal ArticleDOI
Recent Findings on Genetics of Systemic Autoimmune Diseases
Angelica M. Delgado-Vega,Elena Sánchez,Sara E. Löfgren,Casimiro Castillejo-López,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme +6 more
TL;DR: Genome-wide scans analyzing thousands of individuals have now identified most if not all of the major genes involved in susceptibility for several systemic autoimmune diseases.
Journal ArticleDOI
Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.
Casimiro Castillejo-López,Angelica M. Delgado-Vega,Jérôme Wojcik,Sergey V. Kozyrev,Elangovan Thavathiru,Ying-Yu Wu,Elena Sánchez,David Pöllmann,Juan R. López-Egido,Serena Fineschi,Nicolas Dominguez,Rufei Lu,Judith A. James,Joan T. Merrill,Jennifer A. Kelly,Kenneth M. Kaufman,Kenneth M. Kaufman,Kathy L. Moser,Gary S. Gilkeson,Johan Frostegård,Bernardo A. Pons-Estel,Sandra D'Alfonso,Torsten Witte,José Luis Callejas,John B. Harley,John B. Harley,Patrick M. Gaffney,Javier Martín,Joel M. Guthridge,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme +30 more
TL;DR: A genetic interaction between BANK1 and BLK is shown, and it is demonstrated that these molecules interact physically, which has important consequences for the understanding of SLE and other autoimmune diseases and identify a potential new signalling pathway.
Journal ArticleDOI
Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus
Veronica Magnusson,Anna-Karin Lindqvist,Casimiro Castillejo-López,Helga Kristjansdottir,Kristjan Steinsson,Gerdur Grondal,Gunnar Sturfelt,Lennart Truedsson,Elisabet Svenungsson,Ingrid E. Lundberg,I. Gunnarsson,Anne Isine Bolstad,H J Haga,Roland Jonsson,Lars Klareskog,Jorge Alcocer-Varela,Donato Alarcón-Segovia,Joseph D. Terwilliger,Ulf Gyllensten,Marta E. Alarcón-Riquelme +19 more
TL;DR: The results support the presence of the SLEB2 locus at 2q37 and show evidence for association in the single-case and multicase families with locus GAAT3C11 (P < 0.0003), and weak evidence was obtained for several markers located telomeric to D2S125 in the multicase Families.
Journal ArticleDOI
FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes.
Cherno O. Sidibeh,Maria J. Pereira,Xesús M. Abalo,Gretha J. Boersma,Stanko Skrtic,Stanko Skrtic,Per Lundkvist,Petros Katsogiannos,Felix Hausch,Casimiro Castillejo-López,Jan W. Eriksson +10 more
TL;DR: FKBP5 gene expression in human SAT tends to be increased in T2D subjects and is related to elevated glucose levels, and FKBP 5 gene expression is inversely associated with the expression of lipolytic, lipogenic and adipogenic genes.